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Evaluation of allele frequencies in the PADI4 gene and anti-cyclic citrullinated peptide antibodies of patients with rheumatoid arthritis in a Japanese population
  1. M Suzuki1,
  2. J Miyagi1,
  3. M Kuribayashi2,
  4. E Negishi2,
  5. K Ueno2,
  6. H Moriya1
  1. 1Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba City, Japan
  2. 2Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Science, Chiba University
  1. Correspondence to:
    M Suzuki
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana,Chuo-ku, Chiba City, Chiba 2608670, Japan; masahiko{at}

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A case–control linkage disequilibrium study in a Japanese population showed that the peptidyl arginine deiminase type 4 (PADI4) is a susceptibility locus for rheumatoid arthritis (p<0.05).1 Ikari et al2 also showed an association of the PADI4 haplotype with rheumatoid arthritis in an independent Japanese study, but the relationship between the level of anti-cyclic citrullinated peptide (anti-CCP) antibodies and the haplotype has not been shown. Barton et al3,4 and Caponi et al5 could not validate the association in the UK or Caucasian French populations. The purpose of this study was to ascertain the relationship between levels of anti-CCP antibodies and PADI4 allele frequencies in a …

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  • Competing interests: None.

  • Ethical approval: The Graduate School of Medicine, Chiba University, has approved the protocol for this investigation on humans, and all investigations were conducted in conformity with ethical principles of research.

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