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Lupus thrombocytopenia: clinical implications and prognostic significance
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  • Published on: 8 September 2005
    Reply to lupus thrombocytopenia - is it predictable?
    • Michalis Voulgarelis, MD
    • Other Contributors:
      • Panagiotis D. Ziakas, Stavroula Giannouli, Athanasios G. Tzioufas, Michalis Voulgarelis

    Dear Editor,

    The answer is generally “No”.

    Antiphospholipid antibodies/ beta2-glycoprotein I complexes are associated with arterial and venous thrombosis, fetal loss and sometimes with thrombocytopenia, i.e. the antiphospholipid syndrome. However, immune-complex mediated platelet destruction is not a specific mechanism restricted to certain types of immune-complexes.

    Platelets have both immunoglo...

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    Conflict of Interest:
    None declared.
  • Published on: 2 September 2005
    Lupus thrombocytopenia - is it predictable?

    Dear Editor,

    Thrombocytopenia in SLE results from various mechanisms and can be predicted in certain patients with high levels of immune complexes containing beta-2-glycoprotein I. They have also higher levels of serum lipoprotein(a). Thrombocytopenia is considered to be a component of a severe familial form of SLE. The genes at 1q22-23 and 11p13 are linked to this phenotype and to the subsequent high mortality associ...

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    Conflict of Interest:
    None declared.