Article Text

Download PDFPDF

Short course prednisolone for adhesive capsulitis
  1. W A Douglas1
  1. 1201 Wickham Terrace, Brisbane Qld 4000, Australia;
  1. R Buchbinder2
  1. 2Department of Clinical Epidemiology, Cabrini Hospital and Monash Department of Epidemiology and Preventive Medicine, Suite 41, Cabrini Medical Centre, 183 Wattletree Rd, Malvern, Victoria, Australia 3144;

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Adhesive capsulitis is a condition whose pathogenesis remains unclear and for which there is no consensus about the best medical treatment.

Writing recently in the Annals, Buchbinder and her colleagues examined 50 participants (24 receiving active treatment, 26 placebo) from community based rheumatology practices.1 The trial concluded that a “3 week course of 30 mg prednisolone daily is of significant short term benefit in adhesive capsulitis, but benefits are not maintained beyond 6 weeks”.

Although the authors were careful with their inclusion criteria, they failed to set a cut off point from the time of onset of pain and stiffness of the shoulder. Their subjects had a mean (SD) duration of symptoms of 25.3 (13.2) weeks. This indicates that some of the participants in this study had had a frozen shoulder for 38.6 weeks or approximately 9 months. The treatment period was limited to 3 weeks, regardless of the duration of symptoms. There were no other interventions.

Other reported studies have also included patients with long established adhesive capsulitis.2,3 The latter with a mean duration at presentation of 5.5 months before oral corticosteroids were used in a trial.

This study makes an important contribution to the subject, but the authors make the point that future research should evaluate different combinations of treatment and their optimal duration.

Based on my experience, I support this recommendation. I have reported the treatment of 30 patients with idiopathic frozen shoulder (IFS). The mean duration of symptoms before referral was 9 weeks. The treatment was with 1–3 intra-articular injections of betamethasone (Celestone Chronodose) followed by oral prednisone 15–20 mg daily, initially for 2 weeks. A home exercise programme was advised. All 30 patients regained full range of movement of the affected shoulder with freedom from pain and without relapse.4

Future trials should incorporate a treatment group that includes a combination of oral and intra-articular corticosteroids. Double blind trials are problematic given the generally poor outcome for untreated IFS.5 Patients with frozen shoulder with an onset greater than 16 weeks should be excluded from further trials.

IFS is a debilitating condition that is currently perceived as having a poor prognosis. Although it is not life threatening, it has a major impact on quality of life. It is therefore important that rheumatologists establish best practice for the management of this condition and educate other medical practitioners of the value of early, active treatment in achieving good outcomes.


Author’s reply

I thank Dr Douglas for his interest and observations about our trial. He has documented his positive anecdotal experience in treating 30 patients with adhesive capsulitis with a combination of intra-articular and oral corticosteroids in a brief letter to the editor.1 Unfortunately, this has not been published as a full report so no details are provided. It is not clear whether this was an open prospective trial or a retrospective chart review, and, if the latter, whether all patients with adhesive capsulitis were included in the review. Similarly, no numerical data are provided and the time interval between the 1–2 intra-articular steroid injections and the start of oral prednisone was not reported. None the less, his claim that all patients fully recovered, on average 4.5 weeks from initiation of treatment (although no measure of variance is provided) is noteworthy, lends broad support to the conclusions of our trial,2 and, we agree, may warrant a formal trial.

We disagree that double blind trials pose a problem trial in studying adhesive capsulitis, as this is the best method for minimising bias in assessment of treatment outcome. Placebo controlled trials are appropriate when there are no known effective treatments, and controlled trials are essential for self limiting conditions such as adhesive capsulitis. While we agree that adhesive capsulitis is a painful, disabling condition, most studies have in fact established that it has a good prognosis, with resolution of symptoms in 2–3 years, on average, in the majority of patients.2

We also disagree with the suggestion that potential trial participants should be excluded if symptoms have been present for longer than 16 weeks. Although we agree that corticosteroids may be more effective in the earlier phase of adhesive capsulitis, and therefore attempting to limit participation in trials of corticosteroids to those with recent onset of symptoms may appear to have merit, early recruitment has proved universally difficult for trialists in this field.2

Furthermore, our positive trial, which included participants with an average of 21–25 weeks of symptoms, provides clear evidence that this constraint is not necessary.