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Are autoantibodies against a 25-mer synthetic peptide of M3 muscarinic acetylcholine receptor a new diagnostic marker for Sjögren’s syndrome?
  1. P Žigon1,
  2. B Božič1,
  3. S Čučnik1,
  4. B Rozman1,
  5. M Tomšič1,
  6. T Kveder1
  1. 1University Medical Centre, Department of Rheumatology, Ljubljana, Slovenia
  1. Correspondence to:
    MsT Kveder
    University Medical Centre, Department of Rheumatology, Vodnikova 62, SI-1000 Ljubljana, Slovenia;

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We read with great interest the article by Naito and colleagues,1 who recently proposed the autoantibodies against M3 muscarinic acetylcholine receptor (anti-M3R) as a new diagnostic marker for patients with Sjögren’s syndrome (SS).

We have been studying anti-M3R recently2 and reviewed some theoretical aspects.3 The results of our work with the same 25-mer synthetic peptide (K-R-T-V-P-P-G-E-C-F-I-Q-F-L-S-E-P-T-I-T-F-G-T-A-I) as used by Naito et al showed a similar prevalence of anti-M3 in patients with SS (table 1). Nevertheless, we did not draw the same conclusions and could not agree with the statement that antibodies against the 25-mer synthetic peptide might be a new diagnostic marker for SS.

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Table 1

 Anti-M3R antibodies in patients with Sjögren’s syndrome (SS), systemic lupus erythematosus (SLE), and healthy …

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