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Anti-midbody antibodies as a possible predictive factor for a special limited or abortive form of systemic sclerosis?
  1. A K Tausche1,
  2. K Conrad2,
  3. W Seidel3,
  4. B Roch1
  1. 1Section for Internal Medicine, Department of Rheumatology, University Clinic Carl Gustav Carus, Dresden University of Technology, Fetscherstrasse 74, D-01307 Dresden, Germany
  2. 2Institute for Immunology, University Clinic Carl Gustav Carus, Dresden University of Technology, Fetscherstrasse 74, D-01307 Dresden, Germany
  3. 3Medical Clinic IV, Department of Rheumatology, University Clinic Leipzig, Liebigstrasse 22, D-04103 Leipzig, Germany
  1. Correspondence to:
    Dr A-K Tausche
    anne-kathrin.tauschemailbox.tu-dresden.de

https://doi.org/10.1136/ard.2004.034116

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    Autoantibodies (AAb), typically detectable in sera of patients with systemic sclerosis (SSc), are more or less specific and directed against DNA topoisomerase I (Scl-70), centromeric (CENP-B) and nucleolar (fibrillarin, RNA polymerases, Th/To, PM/Scl) antigens and are found also in mixed connective tissue diseases or even before disease manifestation.1,2 In rare cases, AAb to cell cycle associated antigens of the centriole/centrosome, the nuclear mitotic apparatus, the stem body, the cleavage furrow, and the midbody region can be found.3–,5 In the mid-1980s two separate groups described anti-midbody antibodies (aMB) in five patients with SSc and in one patient with Raynaud’s syndrome.4,5 The target antigen(s) of aMB are still unknown proteins of the cleavage furrow and the midbody region of dividing cells and are detected by indirect immunofluorescence on tumour cell monolayer (HEp-2).

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