Article Text

Download PDFPDF

Anti-CD20 monoclonal antibody (rituximab) as an adjunct in the treatment of giant cell arteritis
Free
  1. A Bhatia1,
  2. P J Ell2,
  3. J C W Edwards1
  1. 1Department of Rheumatology, University College London Hospitals, Arthur Stanley House, 40-50 Tottenham Street, London W1T 4NJ, UK
  2. 2Institute of Nuclear Medicine, University College London Hospitals, Middlesex Hospital, Mortimer Street, London W1T 3AA, UK
  1. Correspondence to:
    Professor J C W Edwards
    jo.edwardsucl.ac.uk

Statistics from Altmetric.com

We describe a patient with polymyalgia rheumatica/giant cell arteritis (PMR/GCA) whose disease was refractory to a reduction in the dose of her glucocorticoid to an acceptable level. Our patient improved after B lymphocyte depletion but developed respiratory problems. To our knowledge this is the first description of such a case.

CASE REPORT

An 82 year old woman presented with a 4 week history of symptoms consistent with GCA of the temporal arteries and PMR. Of significance in her past medical history she had significant chronic airflow limitation with an FEV1/FVC (forced expiratory volume in 1 second/forced vital capacity) of 0.7/1.2. Computed tomography of her chest identified a small area of bronchiectasis in the left lower lobe of her chest.

Her erythrocyte sedimentation rate (ESR) and C reactive protein (CRP) were, 109 mm/1st h (normal 1–20) and 230 mg/l (normal 0–5.0), respectively. Treatment was started with 50 mg of prednisolone. Three weeks later …

View Full Text

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.