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Early referral recommendations for ankylosing spondylitis (including pre-radiographic and radiographic forms) in primary care
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  • Published on:
    Response to Drs Healy and Helliwell

    Dear Editor

    Our referral recommendations (1) for axial spondyloarthritis (SpA) that includes ankylosing spondylitis (AS) and early preradiographic forms of axial SpA were based on feasibility, costs, and effectiveness. Two screening parameters have been proposed: inflammatory back pain (IBP) and HLA-B27. According to data presented in an earlier publication (2) we assumed for IBP a sensitivity of 75% and a specific...

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    Conflict of Interest:
    None declared.
  • Published on:
    HLA B27 is not an appropriate screening tool for spondyloarthropathy
    • Paul J Healy, Rheumatology registrar
    • Other Contributors:
      • Philip S. Helliwell

    Dear Editor,

    Sieper et al. propose a set of early referral criteria for ankylosing spondylitis (AS) using HLAB27 as an central test.[1] The supporting data were presented in a previous paper.[2] The HLAB27 data were taken from six study populations. In two groups the control population were either symptom free blood donors or no clinical data was known.[3, 4] There are three published trials using back pain contro...

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    Conflict of Interest:
    None declared.