You are here

Article Text

Article menu
Download PDFPDF
Letters
Fever and increasing cANCA titre after kidney and autologous stem cell transplantation for Wegener’s granulomatosis
  1. T Daikeler1,
  2. C Erley2,
  3. M Mohren3,
  4. C Amberger1,
  5. H Einsele1,
  6. L Kanz1,
  7. I Kötter1
  1. 1Department of Rheumatology, Haematology, Immunology and Oncology, University Hospital Tübingen, Germany
  2. 2Department of Nephrology, University Hospital Tübingen, Germany
  3. 3Department of Haematology, University Hospital Magdeburg, Germany
  1. Correspondence to:
    Dr I Kötter
    Department of Internal Medicine II, University Hospital, Otfried-Müller-Str 10, D-72076 Tübingen, Germany; ina.koettermed.uni-tuebingen.de

https://doi.org/10.1136/ard.2004.029009

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    Wegener’s granulomatosis is a systemic vasculitis mainly affecting the lungs, nasal sinuses, and kidneys. Treatment usually consists of cyclophosphamide (Cy) and steroids.1 High dose Cy with autologous stem cell support could be an alternative treatment for patients resistant to conventional treatment or requiring long term immunosuppression with the risk of secondary malignancy.2

    CASE REPORT

    We report on a 33 year old woman with chronic relapsing sinusitis, pulmonary granuloma, and proteinuria with progressive renal insufficiency since 1988. Renal biopsy showed necrotising glomerulonephritis, and biopsy of the nasal sinus showed granuloma with necrotising vasculitis. Proteinase-3-antineutrophil cytoplasmic antibodies (PR3-ANCA) were detectable with a titre of 1/280. Despite treatment with Cy (750 mg/m2 every 3 weeks, later 100 mg/day orally) and steroids renal function deteriorated, and she underwent dialysis from April 1995 to December 1998. Live kidney transplantation from the patient’s sister matched …

    View Full Text

    Footnotes

    • The first and last authors contributed equally to this work.