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Tenascin-X: a candidate gene for benign joint hypermobility syndrome and hypermobility type Ehlers-Danlos syndrome?
  1. M C Zweers1,
  2. M Kucharekova2,
  3. J Schalkwijk1
  1. 1Department of Dermatology, University Medical Centre Nijmegen, The Netherlands
  2. 2Department of Dermatology, University Hospital Maastricht, The Netherlands
  1. Correspondence to:
    MsM C Zweers
    Department of Dermatology, University Medical Centre Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands;

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Joint hypermobility is a common finding, differing strongly between sexes and among races.1 Joint hypermobility is not a disease in itself, but it can be part of heritable connective tissue disorders, such as Marfan syndrome, Ehlers-Danlos syndrome (EDS), and benign joint hypermobility syndrome (BJHS).2 Although Marfan syndrome and most types of EDS are clinically relatively easy to distinguish by their cardinal features, it is often less easy to differentiate between the hypermobility type of EDS (HT-EDS, formerly type III) and BJHS. Recently, Grahame et al proposed a validated set of diagnostic criteria for BJHS3: the revised Brighton 1998 criteria. Its major criteria are a Beighton score of 4/9 or greater and arthralgia, but …

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