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B cell MALT lymphoma diagnosed by labial minor salivary gland biopsy in patients screened for Sjögren’s syndrome
  1. N M Van Mello1,2,
  2. S R Pillemer1,
  3. P P Tak2,
  4. V Sankar1
  1. 1Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS, Bethesda, MD 20892-1190, USA
  2. 2Division of Clinical Immunology and Rheumatology, Academic Medical Centre, NL-1105, AZ Amsterdam, The Netherlands
  1. Correspondence to:
    Professor P P Tak
    Division of Clinical Immunology and Rheumatology, Academic Medical Centre/University of Amsterdam, F4-218, PO Box 22700, 1100 DE Amsterdam, The Netherlands;


Case report: Three patients presented to the Sjögren’s syndrome (SS) Clinic at the National Institute of Dental and Craniofacial Research for screening. The records of patients with SS with a diagnosis of lymphoma were examined to determine whether the diagnosis was made in any of the cases as a result of labial salivary gland (LSG) biopsies. All patients had typical features of primary SS according to the American-European Consensus Group criteria. B cell mucosa associated lymphoid tissue (MALT) lymphoma was diagnosed based upon the LSG biopsy.

Conclusion: This report underlines the advantages of performing LSG biopsies as a routine part of screening for SS, and shows that it may in some instances lead to early diagnosis of MALT lymphomas in patients who show no signs of pre-existing lymphoma.

  • ANA, antinuclear antibodies
  • ESR, erythrocyte sedimentation rate
  • LSG, labial salivary gland
  • MALT, mucosa associated lymphoid tissue
  • SS, Sjögren’s syndrome
  • MALT lymphoma
  • labial salivary gland biopsy
  • Sjögren’s syndrome

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