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Asthenoazoospermia in patients receiving anti-tumour necrosis factor α agents
  1. G La Montagna,
  2. D Malesci,
  3. R Buono,
  4. G Valentini
  1. Rheumatology Unit of Second University of Naples, via Pansini 5, 80131 Napoli, Italy
  1. Correspondence to:
    Dr G La Montagna
    Unità Operativa di Reumatologia, Seconda Università di Napoli, Via Pansini 5, 80131 Napoli, Italy; giovanni.lamontagnaunina2.it

https://doi.org/10.1136/ard.2005.038620

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    Tumour necrosis factor α (TNFα) is known to affect gonadal cell viability and function by several pathways: inhibiting germ cell apoptosis1; promoting Sertoli cell androgen receptor expression and activity2; and inhibiting Leydig testicular cell steroidogenesis at the transcriptional level.3 Recently, infliximab (that is, …

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