Article Text

Download PDFPDF

Is progressive osteoarthritis an atheromatous vascular disease?
Free
  1. P G Conaghan1,
  2. H Vanharanta2,
  3. P A Dieppe3
  1. 1Academic Unit of Musculoskeletal Disease, University of Leeds, Leeds UK
  2. 2Leeds Musculoskeletal Service, Leeds UK
  3. 3MRC Health Services Research Collaboration, University of Bristol, Bristol UK
  1. Correspondence to:
    Professor P G Conaghan
    Academic Unit of Musculoskeletal Disease, 2nd Floor Chapel Allerton Hospital, Chapeltown Road, Leeds LS7 4SA, UK; p.conaghanleeds.ac.uk

Abstract

Growing evidence from epidemiological studies suggests that osteoarthritis (OA) is linked to atheromatous vascular disease. This hypothesis article proposes that OA, or at least OA structural progression, may be an atheromatous vascular disease of subchondral bone. Further epidemiological studies, imaging investigations of relevant blood vessels, and trials of the effects of statins on the prevention and treatment of OA are needed to examine this hypothesis.

  • MRI, magnetic resonance imaging
  • NSAIDs, non-steroidal anti-inflammatory drugs
  • OA, osteoarthritis
  • osteoarthritis
  • atheromatous vascular disease
  • subchondral bone
View Full Text

Statistics from Altmetric.com

Footnotes

  • Published Online First 17 August 2005

  • Conflict of interest statements: Professor Conaghan has received speaker honoraria and conference expenses from MSD and Pfizer, and has received research grants from AstraZeneca and MSD. Professor Vanharanta and Professor Dieppe have no conflicts of interest.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.