Article Text


Alleviation of polyarticular syndrome in multicentric reticulohistiocytosis with intravenous zoledronate
  1. C P Mavragani1,
  2. K Batziou1,
  3. K Aroni2,
  4. D Pikazis1,
  5. M N Manoussakis1
  1. 1Department of Pathophysiology, Medical School, National University School of Athens, Athens, Greece
  2. 2Department of Pathology, Medical School, National University School of Athens, Athens, Greece
  1. Correspondence to:
    Associate Professor M N Manoussakis
    Department of Pathophysiology, Medical School, National University School of Athens, M Asias 75, 11527, Athens, Greece;

Statistics from

A 67 year old previously healthy women presented with a 12 month history of generalised symmetric arthralgias and bilateral hand contractures. Her past medical history was unremarkable, except for heavy smoking.

On physical examination, she had tight incapacitating flexion contractures of both hands, and small cutaneous non-tender well circumscribed nodules (3–6 mm diameter) on the dorsum of the fingers and over the proximal and distal interphalangeal joints (fig 1). A symmetric polyarthritis affecting the shoulders, elbows, proximal and distal interphalangeal joints, and the knees was prominent. Blood counts, biochemical profile and inflammatory markers, antinuclear antibodies, and rheumatoid factor were within normal limits. A hand x ray examination showed erosive deforming arthropathy of the styloid processes. Biopsy samples of a skin nodule and of synovial membrane disclosed infiltrates of multinucleated giant cells and histiocytes, indicative of multicentric reticulohistiocytosis (MRH). The infiltrating histiocytes were macrophages, as illustrated by positive staining for CD68 marker and negative staining for S-100 (Langerhans’ dendritic cell marker) and HHF-35 actin (fibroblast marker).

Figure 1

 Contraction flexures and cutaneous nodules in the dorsum of the fingers (arrows).

The well described association of MRH with malignancies1,2 had prompted the screening for underlying malignancies, which disclosed a 10-fold increase of CA-125. A pelvic computed tomographic scan was normal; however, magnetic resonance imaging showed the presence of a small well circumscribed mass at the left parametrial space, which was subsequently removed by laparotomy and diagnosed as poorly differentiated ovarian adenocarcinoma without metastatic spread. The patient was given intravenous combination treatment of carbaplatine and cyclophosphamide.

Three months later, the cutaneous nodules resolved, but the polyarthritis persisted and the patient gradually developed a generalised painful stiffness of the trunk and extremities, which required the use of narcotic analgesics and confined her to bed. Intravenous methylprednisolone pulses were also administered, without response. Based on the recently reported effectiveness of intravenous alendronate for MRH,3 zoledronate (4 mg) was given intravenously, because alendronate was unavailable locally. Two weeks later, the stiffness and arthralgias were dramatically reduced. The patient is now completely free of pain and ambulatory.


MRH is a rare disorder of unknown cause, characterised by destructive symmetric arthritis associated with cutaneous papulonodular lesions. In about one third of patients, musculoskeletal symptoms may precede or follow an underlying malignancy (such as breast and ovarian cancer, melanoma or mesothelioma).2 MRH should be differentiated from fibroblastic rheumatism, which is also rare.4 Although strict differentiating histological criteria are lacking, multinucleated foreign body-type giant cells appear to denote MRH, whereas the predominance of myofibroblasts and excessive collagen production characterises fibroblastic rheumatism.5 The inclusion of fibroblastic rheumatism in the broader spectrum of non-Langerhans’ cell histiocytosis has been recently proposed.6

To date, the decision for systemic therapeutic intervention in MRH remains largely empirical. Treatment with steroids and various cytotoxic agents is of questionable efficacy,2 and in our patient it resulted only in resolution of the cutaneous nodules. Recently, the beneficial role of tumour necrosis factor blockers has been suggested7; however, these are contraindicated in patients with concomitant neoplasia. Intravenous alendronate has been also advocated in the management of MRH.4 In our patient, the administration of the parenteral bisphosphonate zoledronate, so far used for the treatment of osteoporosis8 and of hypercalcaemia of malignancy,9 dramatically alleviated the incapacitating joint symptoms.

The precise mechanism of bisphosphonate action on MRH is unclear. However, after intravenous injection, bisphosphonates have been previously shown to deposit in the reticuloendothelial system,10 to inhibit the metalloprotease activity and matrix metalloproteinase-9 expression of infiltrating macrophages,11 and to induce apoptosis of macrophage-like cells.12 Therefore, one may speculate that their favourable effect in MRH is due to the inhibition of tissue infiltration by histiocytes, possibly through induction of apoptosis.


We are indebted to Professor HM Moutsopoulos for inspiration and fruitful suggestions.


View Abstract

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.