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Recurrent oral and genital aphthous ulcerations are the hallmarks of Behçet’s disease. Up to now the various clinical manifestations in Behçet’s disease have been treated with limited success. Recently, clinical observations have reported dramatic responses on clinical signs and symptoms in patients treated with tumour necrosis factor α (TNFα) blocking drugs, including severe mucocutaneous,1–3 gastrointestinal4,5 and ocular manifestations.6
We report the successful treatment with infliximab of a severe longstanding genital ulcer in a patient with Behçet’s disease.
The patient was a 29 year old woman with Behçet’s disease who had had recurrent oral ulcers from age 5 and genital ulcers, arthralgia, and uveitis from age 23. The outbreaks of uveitis were treated with local administration of dexamethasone only. From autumn 2000 the severity of the genital manifestations increased, and treatment with colchicine and prednisolone was started. However, during follow up she still had painful …
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