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Autoimmune thyroiditis and anti-thyroid antibodies in primary Sjögren’s syndrome: a case–control study
  1. R Tunc1,
  2. M S Gonen2,
  3. O Acbay3,
  4. V Hamuryudan4,
  5. H Yazici4
  1. 1Department of Internal Medicine, Division of Rheumatology, Meram School of Medicine, Selcuk University, Konya, Turkey
  2. 2Department of Internal Medicine, Division of Endocrinology, Meram School of Medicine
  3. 3Department of Internal Medicine, Division of Endocrinology, Cerrahpasa School of Medicine, Istanbul University, Istanbul, Turkey
  4. 4Department of Internal Medicine, Division of Rheumatology, Cerrahpasa School of Medicine
  1. Correspondence to:
    Dr Recep Tunc
    Selcuk Universitesi, Meram Tip Fakultesi, Ic Hastalıkları ABD, Romatoloji BD, Konya, Turkey;


Objective: To determine the frequency of antithyroid antibodies and the presence of autoimmune thyroiditis among patients with primary Sjögren’s syndrome.

Design: A case–control study.

Methods: 53 consecutive patients with primary Sjögren’s syndrome, 30 with rheumatoid arthritis, 12 with secondary Sjögren’s syndrome associated with rheumatoid arthritis, 17 with autoimmune thyroiditis, and 53 apparently healthy controls were studied for anti-TG and anti-TPO antibodies as well as serum thyroid hormones and TSH levels.

Results: The overall frequencies of thyroid antibodies were 6/53 (11%) in primary Sjögren’s syndrome, 2/30 (7%) in rheumatoid arthritis, 2/12 (17%) in secondary Sjögren’s syndrome, 4/53 (8%) in healthy controls, and 16/17 (94%) in autoimmune thyroiditis. There was no difference in the frequency of the thyroid antibodies among the groups if patients with autoimmune thyroiditis were excluded (p = 0.415 for anti-TPO; p = 0.275 for anti-TG; p = 0.696 for either anti-TG and/or anti-TPO). Only two patients with primary Sjogren’s syndrome had clinical hypothyroidism associated with autoimmune thyroiditis.

Conclusions: In this Turkish population, no association between primary Sjögren’s syndrome and autoimmune thyroiditis was found.

  • autoimmune thyroiditis
  • Sjögren’s syndrome
  • anti-thyroid antibodies
  • ACR, American College of Rheumatology
  • ANA, antinuclear antibodies
  • anti-TG and anti-TPO, autoantibodies against thyroglobulin and thyroid peroxidase
  • RF, rheumatoid factor
  • TSH, thyroid stimulating hormone

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