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Serum osteoprotegerin but not receptor activator of NF-κB ligand correlates with Larsen score in rheumatoid arthritis
  1. M Skoumal1,
  2. G Kolarz1,
  3. W Woloszczuk2,
  4. G Hawa3,
  5. A Klingler4
  1. 1Institut für Rheumatologie der Kurstadt Baden in Kooperation mit der Donauuniversität Krems, Rheumasonder-krankenanstalt der SVA der gewerblichen Wirtschaft, Baden, Austria
  2. 2Ludwig Boltzmann Institut für experimentelle Endokrinologie, Vienna, Austria
  3. 3Biomedica Medizinprodukte GmbH & Co KG, Austria
  4. 4Theoretical Surgery Unit, Department of General and Transplant Surgery, University Hospital, Innsbruck, Austria
  1. Correspondence to:
    Dr M Skoumal
    Rheumasonderkrankenanstalt der SVA der gewerblichen Wirtschaft, Adolfine Malchergasse 1, 2500 Baden, Austria; martin.skoumala1.net

https://doi.org/10.1136/ard.2002.004507

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    Osteoprotegerin (OPG) is a soluble decoy receptor, produced by osteoblastic cells and in the inflamed synovium of RA by dendritic cells, B cells, and other immunocompetent cells.1,2 It inhibits the differentiation of osteoclast precursor cells and the activation of mature osteoclasts by neutralising the receptor activator of NF-κB ligand (RANKL).3

    RANKL, a member of the tumour necrosis factor family, is expressed on prae-osteoblasts and T lymphocytes. A soluble RANKL (sRANKL) can be produced by activated T lymphocytes or can be generated from the cell bound form by a protease. RANKL itself activates a receptor activator of NF-κB (RANK).4

    RANKL, together with monocyte-colony stimulating factor, interleukin 1, and RANK is responsible for osteoclast formation and activation and inhibits …

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