Infliximab treatment for rheumatoid arthritis, with dose titration based on the Disease Activity Score: dose adjustments are common but not always sufficient to assure sustained benefit

P Sidiropoulos; G Bertsias; H D Kritikos; H Kouroumali; K Voudouris; D T Boumpas

doi:10.1136/ard.2003.015933

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Extended report

Infliximab treatment for rheumatoid arthritis, with dose titration based on the Disease Activity Score: dose adjustments are common but not always sufficient to assure sustained benefit

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	Abstract	Full	Pdf
Jan 2004	172	310	207
Feb 2004	85	263	144
Mar 2004	44	130	66
Apr 2004	32	85	43
May 2004	64	89	36
Jun 2004	60	104	18
Jul 2004	60	79	19
Aug 2004	46	64	16
Sep 2004	38	48	17
Oct 2004	34	61	20
Nov 2004	31	47	12
Dec 2004	17	44	21
Jan 2005	27	40	13
Feb 2005	17	50	36
Mar 2005	22	54	39
Apr 2005	7	44	34
May 2005	19	34	30
Jun 2005	20	40	26
Jul 2005	17	39	36
Aug 2005	10	30	29
Sep 2005	14	28	27
Oct 2005	12	55	44
Nov 2005	16	43	23
Dec 2005	18	41	26
Jan 2006	16	36	25
Feb 2006	14	60	21
Mar 2006	8	36	18
Apr 2006	15	40	23
May 2006	16	32	25
Jun 2006	22	21	10
Jul 2006	8	29	14
Aug 2006	10	22	14
Sep 2006	10	23	13
Oct 2006	13	39	30
Nov 2006	20	42	15
Dec 2006	40	42	18
Jan 2007	23	37	23
Feb 2007	22	43	16
Mar 2007	22	44	17
Apr 2007	26	11	9
May 2007	22	10	14
Jun 2007	35	11	11
Jul 2007	14	11	10
Aug 2007	22	8	8
Sep 2007	22	8	10
Oct 2007	17	5	3
Nov 2007	11	8	7
Dec 2007	12	9	6
Jan 2008	16	6	3
Feb 2008	20	10	12
Mar 2008	32	27	16
Apr 2008	24	4	11
May 2008	25	5	3
Jun 2008	11	8	6
Jul 2008	6	4	3
Aug 2008	13	2	5
Sep 2008	23	4	4
Oct 2008	16	5	6
Nov 2008	24	3	7
Dec 2008	5	3	4
Jan 2009	13	7	7
Feb 2009	21	6	6
Mar 2009	25	5	8
Apr 2009	15	3	6
May 2009	12	3	6
Jun 2009	17	8	1
Jul 2009	14	8	6
Aug 2009	12	2	7
Sep 2009	13	5	7
Oct 2009	25	3	6
Nov 2009	14	3	7
Dec 2009	32	4	8
Jan 2010	12	2	2
Feb 2010	12	5	11
Mar 2010	15	11	15
Apr 2010	8	1	2
May 2010	18	3	4
Jun 2010	15	5	5
Jul 2010	6	4	6
Aug 2010	13	5	5
Sep 2010	5	5	4
Oct 2010	11	7	4
Nov 2010	4	5	4
Dec 2010	8	5	7
Jan 2011	11	2	5
Feb 2011	13	2	0
Mar 2011	8	2	4
Apr 2011	5	1	3
May 2011	6	1	1
Jun 2011	39	3	1
Jul 2011	9	0	1
Aug 2011	10	3	3
Sep 2011	12	2	3
Oct 2011	13	2	6
Nov 2011	11	4	2
Dec 2011	9	9	3
Jan 2012	12	8	7
Feb 2012	18	8	7
Mar 2012	11	3	5
Apr 2012	19	14	7
May 2012	10	9	6
Jun 2012	18	17	8
Jul 2012	27	9	5
Aug 2012	15	10	10
Sep 2012	19	6	5
Oct 2012	23	18	17
Nov 2012	21	11	4
Dec 2012	6	12	6
Jan 2013	20	11	7
Feb 2013	23	8	8
Mar 2013	21	14	7
Apr 2013	32	21	14
May 2013	24	13	2
Jun 2013	6	2	6
Jul 2013	17	6	4
Aug 2013	17	3	11
Sep 2013	23	12	10
Oct 2013	15	13	4
Nov 2013	21	6	5
Dec 2013	16	1	7
Jan 2014	8	2	2
Feb 2014	9	7	3
Mar 2014	14	16	7
Apr 2014	21	10	8
May 2014	29	18	3
Jun 2014	10	8	1
Jul 2014	15	5	2
Aug 2014	8	6	3
Sep 2014	11	9	7
Oct 2014	7	8	3
Nov 2014	10	0	4
Dec 2014	8	8	9
Jan 2015	9	4	0
Feb 2015	17	4	8
Mar 2015	18	11	5
Apr 2015	14	3	3
May 2015	14	6	3
Jun 2015	10	2	2
Jul 2015	20	5	2
Aug 2015	6	2	2
Sep 2015	13	1	1
Oct 2015	5	2	1
Nov 2015	8	3	3
Dec 2015	16	6	2
Jan 2016	19	6	3
Feb 2016	7	1	2
Mar 2016	13	7	2
Apr 2016	10	8	3
May 2016	17	11	2
Jun 2016	3	5	0
Jul 2016	5	7	1
Aug 2016	4	3	2
Sep 2016	16	4	4
Oct 2016	11	4	8
Nov 2016	21	8	4
Dec 2016	16	7	2
Jan 2017	15	14	3
Feb 2017	2	5	3
Mar 2017	1	15	2
Apr 2017	1	15	0
May 2017	2	16	3
Jun 2017	4	15	1
Jul 2017	7	6	3
Aug 2017	12	9	0
Sep 2017	18	16	0
Oct 2017	18	18	7
Nov 2017	53	53	4
Dec 2017	91	87	1
Jan 2018	80	80	0
Feb 2018	53	51	1
Mar 2018	68	66	4
Apr 2018	44	44	0
May 2018	31	31	1
Jun 2018	39	35	3
Jul 2018	31	31	1
Aug 2018	38	36	1
Sep 2018	33	33	1
Oct 2018	44	44	0
Nov 2018	68	66	3
Dec 2018	40	40	3
Jan 2019	53	51	4
Feb 2019	37	33	5
Mar 2019	31	29	8
Apr 2019	25	23	6
May 2019	23	23	5
Jun 2019	22	21	6
Jul 2019	34	30	9
Aug 2019	28	28	7
Sep 2019	33	27	6
Oct 2019	17	18	3
Nov 2019	21	21	4
Dec 2019	19	19	4
Jan 2020	28	26	3
Feb 2020	23	20	6
Mar 2020	19	17	3
Apr 2020	32	25	10
May 2020	19	17	4
Jun 2020	10	10	5
Jul 2020	23	23	4
Aug 2020	13	7	5
Sep 2020	27	27	7
Oct 2020	22	20	4
Nov 2020	24	24	2
Dec 2020	18	17	2
Jan 2021	17	17	5
Feb 2021	22	22	7
Mar 2021	22	16	6
Apr 2021	19	19	4
May 2021	14	12	5
Jun 2021	25	24	12
Jul 2021	5	5	6
Aug 2021	3	3	5
Sep 2021	21	21	2
Oct 2021	27	27	17
Nov 2021	20	19	16
Dec 2021	26	26	1
Jan 2022	18	19	1
Feb 2022	23	21	7
Mar 2022	16	18	6
Apr 2022	28	28	2
May 2022	22	23	16
Jun 2022	34	34	7
Jul 2022	14	13	1
Aug 2022	35	35	5
Sep 2022	40	32	20
Oct 2022	41	39	8
Nov 2022	26	22	7
Dec 2022	21	18	6
Jan 2023	18	18	3
Feb 2023	58	56	1
Mar 2023	26	26	3
Apr 2023	17	10	11
May 2023	15	13	4
Jun 2023	10	10	6
Jul 2023	17	13	26
Aug 2023	6	6	10
Sep 2023	11	9	8
Oct 2023	10	10	1
Nov 2023	26	27	5
Dec 2023	55	20	0
Jan 2024	49	5	1
Feb 2024	48	1	0
Mar 2024	69	3	4
Total	5267	5250	2309

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