Evaluation of the symptomatic and structural efficacy of a new hyaluronic acid compound, NRD101, in comparison with diacerein and placebo in a 1 year randomised controlled study in symptomatic knee osteoarthritis

T Pham; A Le Henanff; Ph Ravaud; P Dieppe; L Paolozzi; M Dougados

doi:10.1136/ard.2003.019703

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Extended report

Evaluation of the symptomatic and structural efficacy of a new hyaluronic acid compound, NRD101, in comparison with diacerein and placebo in a 1 year randomised controlled study in symptomatic knee osteoarthritis

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	Abstract	Full	Pdf
Aug 2004	28	0	19
Sep 2004	65	0	87
Oct 2004	59	0	99
Nov 2004	104	94	87
Dec 2004	125	192	91
Jan 2005	100	122	34
Feb 2005	61	90	16
Mar 2005	62	97	22
Apr 2005	33	104	32
May 2005	48	86	19
Jun 2005	54	70	34
Jul 2005	37	72	13
Aug 2005	27	55	18
Sep 2005	40	91	28
Oct 2005	53	76	18
Nov 2005	50	72	28
Dec 2005	19	86	43
Jan 2006	25	73	34
Feb 2006	17	52	28
Mar 2006	26	88	37
Apr 2006	24	94	41
May 2006	28	95	30
Jun 2006	28	41	17
Jul 2006	19	83	26
Aug 2006	21	82	34
Sep 2006	24	117	44
Oct 2006	30	98	46
Nov 2006	35	87	59
Dec 2006	18	73	44
Jan 2007	26	74	39
Feb 2007	20	91	57
Mar 2007	15	63	45
Apr 2007	62	10	9
May 2007	44	11	17
Jun 2007	35	13	17
Jul 2007	38	31	19
Aug 2007	52	20	13
Sep 2007	63	21	15
Oct 2007	59	22	19
Nov 2007	39	21	17
Dec 2007	31	3	14
Jan 2008	20	12	10
Feb 2008	23	9	10
Mar 2008	34	7	8
Apr 2008	20	5	6
May 2008	25	4	8
Jun 2008	48	10	8
Jul 2008	50	7	11
Aug 2008	56	9	8
Sep 2008	47	11	5
Oct 2008	33	5	6
Nov 2008	27	3	5
Dec 2008	21	3	5
Jan 2009	17	6	6
Feb 2009	38	3	7
Mar 2009	30	9	9
Apr 2009	29	7	8
May 2009	32	4	7
Jun 2009	33	2	5
Jul 2009	44	1	5
Aug 2009	15	11	6
Sep 2009	29	8	8
Oct 2009	28	4	10
Nov 2009	27	2	4
Dec 2009	27	1	8
Jan 2010	34	7	2
Feb 2010	25	3	9
Mar 2010	33	7	4
Apr 2010	19	5	5
May 2010	14	3	4
Jun 2010	17	5	6
Jul 2010	11	4	9
Aug 2010	30	2	4
Sep 2010	29	5	2
Oct 2010	36	1	6
Nov 2010	13	9	5
Dec 2010	23	2	8
Jan 2011	19	6	6
Feb 2011	22	10	2
Mar 2011	30	7	5
Apr 2011	21	8	12
May 2011	18	2	1
Jun 2011	35	2	2
Jul 2011	23	1	5
Aug 2011	20	2	6
Sep 2011	30	0	7
Oct 2011	32	4	4
Nov 2011	22	7	8
Dec 2011	26	26	19
Jan 2012	33	34	18
Feb 2012	20	14	17
Mar 2012	45	19	30
Apr 2012	29	23	30
May 2012	37	18	23
Jun 2012	25	5	31
Jul 2012	60	23	30
Aug 2012	22	19	31
Sep 2012	45	12	34
Oct 2012	30	19	33
Nov 2012	23	16	20
Dec 2012	26	11	14
Jan 2013	28	15	16
Feb 2013	44	13	23
Mar 2013	52	14	20
Apr 2013	26	16	26
May 2013	23	15	22
Jun 2013	20	5	13
Jul 2013	21	9	16
Aug 2013	19	4	12
Sep 2013	33	9	28
Oct 2013	39	6	23
Nov 2013	35	8	14
Dec 2013	38	8	24
Jan 2014	25	5	23
Feb 2014	37	6	13
Mar 2014	19	14	13
Apr 2014	38	9	12
May 2014	17	5	5
Jun 2014	24	5	12
Jul 2014	40	11	9
Aug 2014	49	5	7
Sep 2014	27	10	9
Oct 2014	14	11	6
Nov 2014	14	13	16
Dec 2014	30	7	14
Jan 2015	33	14	10
Feb 2015	22	7	12
Mar 2015	20	21	15
Apr 2015	18	10	15
May 2015	15	4	7
Jun 2015	25	6	5
Jul 2015	42	12	11
Aug 2015	17	11	21
Sep 2015	26	13	10
Oct 2015	10	8	5
Nov 2015	14	9	7
Dec 2015	74	7	4
Jan 2016	48	5	9
Feb 2016	13	7	6
Mar 2016	17	15	15
Apr 2016	0	7	7
May 2016	19	8	7
Jun 2016	14	2	10
Jul 2016	21	5	5
Aug 2016	13	6	12
Sep 2016	34	16	12
Oct 2016	45	9	16
Nov 2016	28	6	10
Dec 2016	14	2	2
Jan 2017	8	2	4
Feb 2017	9	6	6
Mar 2017	17	16	9
Apr 2017	10	15	8
May 2017	7	19	17
Jun 2017	15	11	5
Jul 2017	14	6	4
Aug 2017	27	23	11
Sep 2017	26	12	6
Oct 2017	39	17	9
Nov 2017	30	18	9
Dec 2017	28	14	3
Jan 2018	35	19	7
Feb 2018	28	20	15
Mar 2018	30	16	11
Apr 2018	21	8	5
May 2018	26	14	6
Jun 2018	27	15	10
Jul 2018	21	15	8
Aug 2018	25	15	6
Sep 2018	17	11	6
Oct 2018	15	11	1
Nov 2018	12	12	6
Dec 2018	28	18	3
Jan 2019	32	20	8
Feb 2019	20	11	6
Mar 2019	23	19	20
Apr 2019	24	20	16
May 2019	14	12	9
Jun 2019	24	14	18
Jul 2019	22	16	14
Aug 2019	16	10	10
Sep 2019	31	11	10
Oct 2019	31	23	6
Nov 2019	12	6	16
Dec 2019	28	16	11
Jan 2020	35	27	15
Feb 2020	29	20	8
Mar 2020	15	12	13
Apr 2020	179	177	14
May 2020	19	13	8
Jun 2020	17	17	7
Jul 2020	21	13	7
Aug 2020	12	10	7
Sep 2020	42	33	9
Oct 2020	17	14	15
Nov 2020	33	24	16
Dec 2020	10	8	6
Jan 2021	13	10	8
Feb 2021	16	8	6
Mar 2021	15	9	14
Apr 2021	18	16	6
May 2021	19	18	16
Jun 2021	9	9	10
Jul 2021	14	14	12
Aug 2021	12	12	20
Sep 2021	13	14	9
Oct 2021	31	18	27
Nov 2021	27	21	19
Dec 2021	19	17	7
Jan 2022	35	23	15
Feb 2022	35	28	14
Mar 2022	36	34	9
Apr 2022	45	33	15
May 2022	33	25	26
Jun 2022	38	30	23
Jul 2022	51	35	15
Aug 2022	53	44	21
Sep 2022	40	32	18
Oct 2022	35	29	8
Nov 2022	23	17	24
Dec 2022	32	25	13
Jan 2023	22	22	11
Feb 2023	36	33	8
Mar 2023	29	16	10
Apr 2023	20	14	19
May 2023	35	25	12
Jun 2023	17	16	2
Jul 2023	37	27	25
Aug 2023	23	13	12
Sep 2023	11	11	8
Oct 2023	26	24	13
Nov 2023	20	18	6
Dec 2023	57	11	3
Jan 2024	59	13	2
Feb 2024	79	2	1
Mar 2024	186	8	3
Total	7308	5240	3577

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