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Evaluation of the symptomatic and structural efficacy of a new hyaluronic acid compound, NRD101, in comparison with diacerein and placebo in a 1 year randomised controlled study in symptomatic knee osteoarthritis
  1. T Pham1,
  2. A Le Henanff2,
  3. Ph Ravaud2,
  4. P Dieppe3,
  5. L Paolozzi4,
  6. M Dougados4
  1. 1Conception Hospital, AP-HM, Service de Rhumatologie Sud, Marseille, France
  2. 2Groupe Hospitalier Bichat-Claude Bernard, AP-HP, Xavier Bichat University, Paris, France
  3. 3Health Services Research Collaboration, University of Bristol, Bristol, UK
  4. 4Cochin Hospital, AP-HP, René Descartes University, Paris, France
  1. Correspondence to:
    Professor M Dougados
    Rheumatology B Department, Cochin Hospital, 27 rue du Faubourg Saint Jacques, 75014 Paris, France;


Objective: To evaluate long term efficacy of three iterative courses of three weekly intra-articular (IA) injections of NRD101 in the treatment of symptomatic knee osteoarthritis (OA).

Patients and methods: A 1 year prospective, multicentre, randomised, double blind, placebo controlled study of 301 patients aged >50 years with painful and radiological medial knee OA. Patients were randomly assigned into three groups receiving: (1) three courses of three IA injections of hyaluronic acid (HA) + oral placebo; (2) IA injections of saline solution + diacerein 100 mg/day; (3) IA injections of saline solution + oral placebo. Demographic data and symptomatic criteria—pain, Lequesne’s index, patient’s global assessment of disease activity, percentage of painful days—were obtained during the study; primary structural criterion was JSW. Efficacy criteria were changes in pain VAS, joint space narrowing (JSN), and percentage of progressors (JSN >0.5 mm). An intention to treat analysis was used for symptomatic variables, and completer analysis for structural variables.

Results: Baseline characteristics were similar between the three groups. Mean (SD) improvement in pain VAS was clinically relevant (−33.9 (27.3), n = 301), but with no difference between the groups (p = 0.96). JSW deteriorated (−0.09 (0.55) mm, n = 277, p = 0.01), but with no difference between the groups (p = 0.82). Percentages of progressors were 17.7, 18.9, and 20.3% (p = 0.90), in groups 1, 2, and 3, respectively.

Conclusion: A weak but statistically significant structural deterioration occurred over 1 year, together with clinically relevant symptomatic improvement in patients receiving oral drug and iterative IA injections. Symptomatic and/or structural effects for both this new HA compound and diacerein were not demonstrated.

  • HA, hyaluronic acid
  • IA, intra-articular
  • JSN, joint space narrowing
  • JSW, joint space width
  • NSAIDs, non-steroidal anti-inflammatory drugs
  • OA, osteoarthritis
  • VAS, visual analogue scale
  • NRD101
  • diacerein
  • hyaluronic acid
  • knees
  • osteoarthritis
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