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How the type of risk reduction influences required sample sizes in randomised clinical trials
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  • Published on:
    Should patients with medium risk of disease progression really be avoided in clinical trials?
    • Jane S Angwin
    • Other Contributors:
      • Michael Binks, Michael F. James

    Dear Editor,

    Patient selection can affect required sample sizes and outcomes in randomised clinical trials and the optimal selection may depend on how the tested drug differentially affects patients. Bruynesteyn K et al. [1,2] have investigated these effects in rheumatoid arthritis based on an outcome measure of radiological damage progression.

    An absolute reduction (AR) drug which reduces the expe...

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    Conflict of Interest:
    None declared.