Article Text

Download PDFPDF
Visceral leishmaniasis resembling systemic lupus erythematosus
  1. P V Voulgari1,
  2. G A Pappas1,
  3. E N Liberopoulos1,
  4. M Elisaf1,
  5. F N Skopouli2,
  6. A A Drosos1
  1. 1Department of Internal Medicine, Medical School, University of Ioannina, Greece
  2. 2Department of Nutrition and Dietetics, University of Harokopion, Athens, Greece
  1. Correspondence to:
    Professor A A Drosos
    Department of Internal Medicine, Medical School, University of Ioannina, 45110 Ioannina, Greece;

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease of unknown aetiology. B cell hyperactivity with production of multiple autoantibodies is the hallmark of the disease.1 On the other hand, such polyclonal B cell activation may occur in chronic infectious diseases. In this report we present a patient with visceral leishmaniasis who was diagnosed as having SLE and we discuss the clinical and laboratory findings which may discriminate between these two entities.


A 50 year old man presented in October 2001 with arthralgias, fatigue, weight loss, and low grade fever. Laboratory evaluation revealed haemoglobin 110 g/l, white blood cells 3.9×109/l with normal differential count, platelets 90×109/l, and erythrocyte sedimentation rate (ESR) 50 mm/1st h.

He was admitted to the hospital where physical examination disclosed mild splenomegaly. A laboratory investigation confirmed anaemia, leucopenia, and thrombocytopenia, increased ESR and C reactive protein (CRP) (table 1). Renal, liver and thyroid …

View Full Text