Background: Fas mediated apoptosis may be important in the pathogenesis of primary Sjögren’s syndrome (pSS).
Objective: To examine genetic variation in the promoter region of the Fas gene in pSS.
Methods: Two single nucleotide polymorphisms at positions −1377(G/A) and −670(G/A) in the Fas gene promoter were genotyped by PCRSSP in 101 patients with pSS and 108 Caucasoid controls.
Results: No significant differences in allele or genotype frequencies were detected between the patients with pSS and controls. However, significant associations were observed with Ro/La autoantibody negative patients, who display milder and later onset disease. The −670A allele was more frequent in Ro/La autoantibody negative patients than in Ro/La autoantibody positive patients (p = 0.04).
Conclusion: This study does not confirm an earlier report of an association between pSS and the Fas promoter −670G allele. However, the results suggest that genetically determined variability in Fas expression may modulate Ro/La autoantibody responses in patients with pSS.
- Sjögren’s syndrome
- CIE, counterimmunoelectrophoresis
- ELISA, enzyme linked immunosorbent assay
- pSS, primary Sjögren’s syndrome
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Support and financial interests: none.
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