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The antiphospholipid syndrome II
  1. M Bijl,
  2. C G M Kallenberg

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The Antiphospholipid Syndrome II, subtitled Autoimmune Thrombosis, aims to give an overview, in four parts, of this intriguing syndrome. First is a brief overview of the history and epidemiology, a second part deals with immunology and pathophysiology, a third deals with clinical features, and, finally, several chapters discuss management and prognosis of the syndrome. Each part consists of a series of topics written by authorities in the field. The separate chapters can be considered as in-depth reviews of the item discussed.

As suggested by the title, all aspects of the syndrome are highlighted. Most chapters have a structured format, are illustrated, and well referenced. References are updated to 2001. The subject index is useful and directs the reader adequately to the items searched for. The book is especially suited for such an approach because the introduction to each chapter supplies the reader with similar, general information about the APS. Moreover, various chapters overlap. The reason probably is that the chapters are somewhat heterogeneous in selecting studies and topics to be discussed, and are not always restricted to didactic overviews. For use in clinical practice the book would have gained by including diagnostic flow diagrams and discussion on differential diagnostic dilemmas. The ultimate answers of how to deal with certain clinical situations are lacking, simply because these answers are not available yet. APS is studied extensively and further insights are developing continuously, making parts of a book like this quickly outdated.

Nevertheless, The Antiphospholipid Syndrome II is a very valuable source for those who want to have an overview of the great progress which has been made in fundamental research, the increasing pathophysiological insights and the current treatment modalities in APS. It is particularly useful for researchers and of value for clinicians dealing with patients with APS and the various disease manifestations these patients can develop.

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