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Normal intestinal microbiota in the aetiopathogenesis of rheumatoid arthritis
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  • Published on:
    Continuous seeding of degraded products of normal micro-organisms as a causative factor in RA
    • Adriaan C. Breebaart, Professor Emeritus of Ophthalmology
    • Other Contributors:
      • Johannes J.W.Bijlsma and Willem van Eden

    Dear Editor

    Toivanen [1] put forward the interesting hypothesis that, in contrast to reactive arthritis where temporary lodging of pathogenic micro- organisms is a causative factor, in RA a continuous seeding of degraded bacterial products from normal intestinal flora may induce synovitis. This hypothesis closely resembles the theory published by us one year earlier,[2] in which we also stressed a continuous seeding o...

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    Conflict of Interest:
    None declared.