High incidence of hepatotoxicity of isoniazid treatment for tuberculosis chemoprophylaxis in patients with rheumatoid arthritis treated with methotrexate or sulfasalazine and anti-tumour necrosis factor inhibitors

J Vanhoof; S Landewe; E Van Wijngaerden; P Geusens

doi:10.1136/ard.2002.004598

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Letter

High incidence of hepatotoxicity of isoniazid treatment for tuberculosis chemoprophylaxis in patients with rheumatoid arthritis treated with methotrexate or sulfasalazine and anti-tumour necrosis factor inhibitors

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	Abstract	Full	Pdf
Nov 2003	0	66	31
Dec 2003	0	82	71
Jan 2004	0	78	45
Feb 2004	0	59	33
Mar 2004	0	40	55
Apr 2004	0	23	10
May 2004	1	59	12
Jun 2004	0	54	13
Jul 2004	0	59	10
Aug 2004	0	118	38
Sep 2004	1	105	21
Oct 2004	24	25	23
Nov 2004	22	26	4
Dec 2004	37	32	20
Jan 2005	25	65	29
Feb 2005	15	53	19
Mar 2005	25	80	19
Apr 2005	12	46	30
May 2005	7	45	13
Jun 2005	18	47	23
Jul 2005	16	55	30
Aug 2005	16	37	15
Sep 2005	9	34	12
Oct 2005	12	67	17
Nov 2005	8	50	11
Dec 2005	13	49	19
Jan 2006	23	48	11
Feb 2006	10	33	8
Mar 2006	12	39	20
Apr 2006	10	42	17
May 2006	15	37	8
Jun 2006	31	24	5
Jul 2006	9	43	10
Aug 2006	16	63	11
Sep 2006	18	50	4
Oct 2006	9	36	9
Nov 2006	8	58	11
Dec 2006	10	49	13
Jan 2007	8	78	13
Feb 2007	4	51	8
Mar 2007	7	65	4
Apr 2007	56	10	2
May 2007	40	22	6
Jun 2007	61	13	3
Jul 2007	40	38	9
Aug 2007	50	15	9
Sep 2007	40	13	4
Oct 2007	27	18	17
Nov 2007	36	13	9
Dec 2007	31	9	3
Jan 2008	43	10	4
Feb 2008	43	11	3
Mar 2008	44	16	9
Apr 2008	24	10	9
May 2008	36	12	6
Jun 2008	32	13	5
Jul 2008	30	13	4
Aug 2008	57	9	6
Sep 2008	51	11	3
Oct 2008	40	6	3
Nov 2008	26	3	3
Dec 2008	19	1	1
Jan 2009	33	4	4
Feb 2009	34	11	6
Mar 2009	40	13	5
Apr 2009	29	8	3
May 2009	26	11	10
Jun 2009	37	5	2
Jul 2009	48	7	1
Aug 2009	28	6	1
Sep 2009	28	11	0
Oct 2009	44	8	4
Nov 2009	37	8	7
Dec 2009	36	5	7
Jan 2010	31	8	2
Feb 2010	19	5	6
Mar 2010	31	12	4
Apr 2010	37	11	3
May 2010	25	2	1
Jun 2010	29	13	3
Jul 2010	20	7	7
Aug 2010	21	5	5
Sep 2010	12	6	3
Oct 2010	11	10	5
Nov 2010	15	5	4
Dec 2010	18	2	2
Jan 2011	11	5	0
Feb 2011	17	5	4
Mar 2011	11	8	4
Apr 2011	7	3	3
May 2011	9	1	4
Jun 2011	22	6	5
Jul 2011	20	3	5
Aug 2011	19	2	2
Sep 2011	21	5	4
Oct 2011	10	1	1
Nov 2011	20	6	4
Dec 2011	4	13	10
Jan 2012	4	11	9
Feb 2012	7	5	6
Mar 2012	13	10	3
Apr 2012	5	11	8
May 2012	5	15	5
Jun 2012	6	10	6
Jul 2012	15	11	3
Aug 2012	6	13	6
Sep 2012	8	10	6
Oct 2012	4	10	7
Nov 2012	0	19	10
Dec 2012	0	15	4
Jan 2013	0	15	7
Feb 2013	0	5	6
Mar 2013	0	7	1
Apr 2013	0	11	7
May 2013	0	4	4
Jun 2013	3	11	1
Jul 2013	5	7	6
Aug 2013	5	9	6
Sep 2013	3	6	4
Oct 2013	4	15	2
Nov 2013	2	5	0
Dec 2013	2	3	19
Jan 2014	2	14	5
Feb 2014	1	7	9
Mar 2014	8	14	11
Apr 2014	8	11	5
May 2014	9	21	1
Jun 2014	1	14	1
Jul 2014	7	26	3
Aug 2014	1	11	3
Sep 2014	0	9	1
Oct 2014	3	16	7
Nov 2014	0	25	9
Dec 2014	2	11	14
Jan 2015	8	13	10
Feb 2015	0	16	13
Mar 2015	9	15	4
Apr 2015	1	18	4
May 2015	2	19	9
Jun 2015	7	13	5
Jul 2015	3	12	4
Aug 2015	1	15	5
Sep 2015	11	26	9
Oct 2015	3	9	8
Nov 2015	2	7	2
Dec 2015	6	20	5
Jan 2016	4	10	6
Feb 2016	1	14	4
Mar 2016	5	13	16
Apr 2016	6	20	8
May 2016	7	10	2
Jun 2016	4	17	11
Jul 2016	3	15	6
Aug 2016	6	12	7
Sep 2016	3	14	8
Oct 2016	6	13	5
Nov 2016	10	10	16
Dec 2016	11	17	5
Jan 2017	4	5	5
Feb 2017	4	6	2
Mar 2017	0	8	4
Apr 2017	1	10	5
May 2017	0	18	6
Jun 2017	3	16	17
Jul 2017	24	24	8
Aug 2017	18	18	9
Sep 2017	25	25	6
Oct 2017	25	17	4
Nov 2017	24	24	7
Dec 2017	54	48	4
Jan 2018	30	28	6
Feb 2018	37	33	5
Mar 2018	25	25	1
Apr 2018	31	27	4
May 2018	15	15	1
Jun 2018	25	25	4
Jul 2018	24	24	8
Aug 2018	40	40	19
Sep 2018	34	34	9
Oct 2018	39	39	4
Nov 2018	59	59	8
Dec 2018	42	42	7
Jan 2019	36	36	9
Feb 2019	34	35	13
Mar 2019	40	40	7
Apr 2019	45	44	12
May 2019	60	60	22
Jun 2019	33	33	12
Jul 2019	33	33	11
Aug 2019	27	27	8
Sep 2019	36	37	8
Oct 2019	42	42	9
Nov 2019	44	44	13
Dec 2019	34	33	8
Jan 2020	37	36	11
Feb 2020	28	28	5
Mar 2020	18	18	7
Apr 2020	33	33	24
May 2020	28	28	11
Jun 2020	26	25	8
Jul 2020	21	21	8
Aug 2020	17	16	13
Sep 2020	48	44	5
Oct 2020	30	29	10
Nov 2020	31	30	11
Dec 2020	18	18	2
Jan 2021	31	31	14
Feb 2021	29	29	4
Mar 2021	20	20	8
Apr 2021	17	17	4
May 2021	26	24	3
Jun 2021	22	22	6
Jul 2021	13	13	6
Aug 2021	12	11	7
Sep 2021	20	20	4
Oct 2021	20	20	18
Nov 2021	18	18	16
Dec 2021	24	24	10
Jan 2022	20	20	9
Feb 2022	26	26	9
Mar 2022	16	16	5
Apr 2022	21	21	9
May 2022	29	29	8
Jun 2022	23	23	7
Jul 2022	21	21	0
Aug 2022	23	23	3
Sep 2022	36	36	12
Oct 2022	30	30	5
Nov 2022	30	29	5
Dec 2022	16	16	7
Jan 2023	20	20	6
Feb 2023	57	55	14
Mar 2023	20	20	9
Apr 2023	18	21	6
May 2023	28	29	6
Jun 2023	18	18	3
Jul 2023	35	35	7
Aug 2023	71	71	7
Sep 2023	32	32	3
Oct 2023	20	20	2
Nov 2023	37	37	1
Dec 2023	63	14	1
Jan 2024	63	8	3
Feb 2024	83	9	11
Mar 2024	70	14	2
Total	4955	5784	2071

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