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Synovial lymphocyte responses if tested fresh not frozen can incriminate microbial intrasynovial DNA and RNA
  1. D K Ford
  1. University of British Columbia, 4380 Locarno Crescent, Vancouver BC, Canada V6R 1G3
  1. Correspondence to:
    Professor D K Ford;
    d.ford{at}telus.net

https://doi.org/10.1136/ard.62.10.1027

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    In a previous issue of the Annals, Sibilia and Limbach reviewed the microbiology of “infectious arthritis” and described various ways in which the agents might be related to the arthritis.1 One approach, for which there is considerable support, was, however, not discussed.

    In 1980 synovial lymphocytes were found to respond maximally to stimulation by either chlamydia or ureaplasma antigens in cases of sexually transmitted reactive arthritis.2 In 1985 synovial responses were reported in eight cases of enteric and 12 cases of sexually transmitted reactive arthritis.3 Responses to the relevant antigens of each category differentiated the enteric from the sexually transmitted cases. Additionally, peripheral blood lymphocytes in all eight enteric cases and in …

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