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Letter
Thrombophilia and thrombosis in systemic lupus erythematosus: a case-control study
  1. D Barcat1,
  2. V Guérin2,
  3. A Ryman2,
  4. J Constans1,
  5. J P Vernhes3,
  6. C Vergnes4,
  7. F Bonnet5,
  8. X Delbrel5,
  9. P Morlat5,
  10. M Longy-Boursier5,
  11. C Conri1
  1. 1Médecine Interne et Pathologie Vasculaire, Hôpital Saint-André, 1, rue Jean Burguet, 33075 Bordeaux, France
  2. 2Hématologie, Hôpital Pellegrin, 3, place Amélie Raba-Léon, 33076 Bordeaux, France
  3. 3Rhumatologie, Hôpital Robert Boulin, 33500 Libourne, France
  4. 4Hématologie, Hôpital du Haut Lévêque, 33600 Pessac, France
  5. 5Médecine Interne et Pathologie Infectieuse, Hôpital Saint-André, 1, rue Jean Burguet, 33075 Bordeaux, France
  1. Correspondence to:
    Dr D Barcat;
    damien.barcat{at}chu-bordeaux.fr

https://doi.org/10.1136/ard.62.10.1016

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    Antiphospholipid/cofactor antibodies are detected in only 60% of patients with systemic lupus erythematosus (SLE) with thrombosis.1 Therefore, we studied thrombophilia factors and their relation with thrombosis in patients with SLE.

    METHODS AND RESULTS

    Forty eight consecutive patients with SLE were included (39 women, 9 men), 15 with and 33 without past thrombosis (Th and NTh group, respectively). Twenty thrombotic events were identified: 17 deep venous and 1 arterial thrombosis, 2 osteonecrosis. Both groups had comparable clinical, biological, therapeutic data, and mean (SD) SLE disease activity index (SLEDAI) (5 (4.6) v 5.3 (4.8)).

    Patients were examined at least one month after thrombosis (>3 months in 11 out of 15). The following parameters were determined: protein C, total and free …

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