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CD5+ B cells and uveitis
  1. J Jiménez-Alonso1,
  2. M Omar1,
  3. M A López-Nevot2,
  4. F Pérez-Álvarez1,
  5. M Toribio3,
  6. C Hidalgo1,
  7. J M Sabio1
  1. 1Systemic Autoimmune Diseases Unit, Services of Internal Medicine, “Virgen de las Nieves” University Hospital, Granada, Spain
  2. 2Clinical Immunology, “Virgen de las Nieves” University Hospital
  3. 3Ophthalmology, “Virgen de las Nieves” University Hospital
  1. Correspondence to:
    Dr J Jiménez-Alonso, 9th floor, Hospital Universitario “Virgen de las Nieves”, Avda Fuerzas Armadas No 2, 18012 Granada, Spain;

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High levels of circulating B1a lymphocytes expressing CD5 have been reported in some patients with non-organ-specific autoimmune diseases, such as systemic lupus erythematosus, primary Sjögren’s syndrome, and rheumatoid arthritis, although CD5+ B cells do not seem to be only agents of autoantibody production.1 Thus, B cells display a variety of characteristics other than antibody production—for example, in lymphoid architecture development, regulation of T cell subsets and antigen presenting cell function through cytokine production, and in activation of T cells.2,3 In addition, CD5+ B cells have a role in several organ-specific autoimmune diseases, such as chronic urticaria,4 insulin dependent diabetes mellitus,5 myasthenia gravis,6 and immune thrombocytopenic purpura, where the increased proportion of CD5+ B cells in spleen and peripheral blood, and …

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