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Extremely high dose pravastatin may suppress amyloidogenesis in a mouse model
  1. S Shtrasburg,
  2. M Pras,
  3. M Lidar,
  4. A Livneh
  1. Heller Institute of Medical Research, Sheba Medical Centre, Tel-Hashomer, Israel
  1. Correspondence to:
    Dr S Shtrasburg, Heller Institute of Medical Research, Sheba Medical Centre, Tel Hashomer 52621, Israel;
    shmuels{at}sheba.health.gov.il

https://doi.org/10.1136/ard.61.6.572

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    Pravastatin is a cholesterol lowering agent,1 recently reported to have anti-inflammatory properties.2 It was suggested that the prevention and regression of atherosclerosis by pravastatin is partially related to its anti-inflammatory effect,2 probably mediated by inhibition of proinflammatory cytokines.3 Pravastatin's anti-inflammatory effect is associated with, and probably reflected by, reduced levels of the acute phase reactants, C reactive protein and serum amyloid A (SAA).2 The N-terminal fragment of the SAA is amyloid A (AA), which is deposited in a fibrillar form in the tissues of up to 30% of patients with a variety of …

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