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Fatigue and immune activity in Sjögren's syndrome
  1. H I Bax1,
  2. T M Vriesendorp1,
  3. C G M Kallenberg1,
  4. W W I Kalk2
  1. 1Department of Clinical Immunology, University Hospital Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands
  2. 2Department of Oral and Maxillofacial Surgery, University Hospital Groningen
  1. Correspondence to:
    Dr W W I Kalk, Department of Oral and Maxillofacial Surgery, University Hospital Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands;
    w.w.i.kalk{at}kchir.azg.nl

https://doi.org/10.1136/ard.61.3.284

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    Despite major desiccation of mucous membranes in Sjögren's syndrome (SS), fatigue is often experienced by patients as the most disabling complaint.1,2 Unfortunately, there is no proper treatment available to combat the fatigue in SS. Beside a variety of somatic and non-somatic conditions,2–,6 increased immune activity has been implicated as a cause of fatigue in autoimmune diseases.6,7 If responsible for fatigue in SS, it could serve as a treatment target. The purpose of this study was, therefore, to examine the relation between fatigue and immune variables in SS.

    Thirty six consecutive patients with primary SS visiting our outpatient departments participated in this study. Two control groups were used: a group of 18 patients diagnosed with secondary SS, and a …

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