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Pathological basis of orthopaedic and rheumatic disease
  1. C A Seemayer,
  2. R E Gay,
  3. S Gay

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    The author provides an overview of the pathology of orthopaedic and rheumatic diseases which could help pathologists in finding the correct diagnosis and also support clinicians and rheumatic disease oriented researchers in obtaining information about a broad range of distinct pathological disorders.

    There are eight chapters starting with skeletal structure development and progressing to injuries, infections, disorders of the skeletal development, and metabolic and other generalised diseases of the skeleton. Final chapters deal with diseases of articular tissues, including osteoarthritis and rheumatoid arthritis, and also describe tumours and tumour-like lesions of bone and soft tissue. The last two chapters covering tumour pathology comprise 40% of the content.

    Each chapter stands by itself and, therefore, it is possible to focus directly on the matter of interest. The structure of description of the particular disease is consistent and logical and helpful to the reader. The normal format is a short introduction to the disease, some clinical features, radiological features, gross pathology, and histopathology. Every chapter ends with a list of references. The author quotes more than 1500 citations. More than 250 figures including histology, gross pathology, radiological pictures, and schematic diagrams and many tables enrich the quality of the volume.

    In a future edition, inclusion of colour figures and an indication of the magnification of the histology pictures would be helpful. From our point of view working in the field of rheumatoid arthritis, the subchapter dealing with the disease could be extended, because the incidence of rheumatoid arthritis is 1–3% in Western countries.

    What is missing is any reference throughout the text to the molecular and cellular mechanisms of the diseases. However, we suggest that this single volume would be useful for everyone interested in a summary of histological features of numerous orthopaedic and rheumatic diseases as seen in the clinic.

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