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Letter
ANCA antibodies in Graves' disease
  1. M Gumà1,
  2. A Olivé1,
  3. M Juan2,
  4. I Salinas3
  1. 1Rheumatology Section, Hospital Universitari Germans Trias i Pujol, Crta del Canyet s/n Badalona, 08916 Barcelona, Spain; aolive@ns.hugtip.scs.es
  2. 2Immunology Section, Hospital Universitari Germans Trias i Pujol
  3. 3Endocrinology Section, Hospital Universitari Germans Trias i Pujol
  1. Correspondence to:
    Dr A Olivé

https://doi.org/10.1136/ard.61.1.90

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    Several drugs have been associated with antineutrophil cytoplasmic antibodies (ANCA) positivity—namely, hydralazine, penicillamine, allopurinol, and propylthiouracil.1

    Although propylthiouracil is often implicated in the induction of ANCA positive vasculitis,2,3 other antithyroid drugs, such as carbimazole and thiamazole, have been linked.4,5 Furthermore, ANCA positivity has been described in the course of Graves' disease without vasculitis.6

    This study aimed at determining the frequency and specificity of ANCA in a series of patients with Graves' disease.

    We retrospectively examined 35 serum samples from patients with Graves' disease. Diagnosis of the disease was based on typical signs and symptoms of hyperthyroidism, raised serum …

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