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Methotrexate and postoperative complications
  1. A Wluka1,
  2. R Buchbinder2,
  3. S Hall3,
  4. G Littlejohn4
  1. 1Department of Epidemiology and Preventive Medicine, Monash University, Australia
  2. 2Department of Epidemiology, Cabrini Hospital, Malvern, Australia and Monash University, Australia
  3. 3Cabrini Medical Centre, Malvern, Australia
  4. 4Monash Medical Centre, Clayton, Australia
  1. Correspondence to:
    Dr A Wluka, Department of Epidemiology and Preventive Medicine, Monash University, Central and Eastern Clinical School, Alfred Hospital, Prahran, Victoria 3181, Australia

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Grennan et al report the safety of continued methotrexate in the perioperative period.1 Previous investigators have despaired of answering this question definitively owing to the difficulty in recruiting subjects.2 It is reassuring to see that methotrexate use throughout the postoperative period does not interfere with wound healing or increase the incidence of early complications.

Despite this important finding, we believe that the results of this study should be regarded with some reservation: continuation of methotrexate throughout the perioperative period should be accompanied by significant …

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