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Hypothesis
Could inflammatory arthritis be triggered by progenitor cells in the joints?

Abstract

Fetal morphogenesis genes are expressed in rheumatoid synovial tissue and the presence of undifferentiated mesenchymal cells can also be shown. Possibly, these events are related to remodelling/repair processes, which could lead to the development of new methods of treatment, or they may be harmful and play a part in the immune process.

  • inflammatory arthritis
  • progenitor cells
  • joints
  • BMP, bone morphogenetic protein
  • FGF, fibroblast growth factor
  • IL, interleukin
  • NFAT, nuclear factor of activated T cells
  • PG, proteoglycan
  • RA, rheumatoid arthritis
  • rBMP, recombinant BMP
  • TGFβ, transforming growth factor β
  • Wnt, wingless

https://doi.org/10.1136/ard.61.1.6

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    • Leader
      Mesenchymal precursor cells
      M Corr N J Zvaifler
      Annals of the Rheumatic Diseases 2002; 61 3-5 Published Online First: 01 Jan 2002. doi: 10.1136/ard.61.1.3