Objectives To assess the prevalence of IL-10 and IL-6 polymorphisms in patients with early rheumatoid arthritis (RA) in our population and investigate whether there is an association with radiographic severity.
Methods 68 patients with early RA (49F/19M, mean age 51 ± 15 y, mean disease duration 15 ± 13 mo, RF+ 72%, mean number of swollen joints at entry 8.23 ± 7.33). Patients were genotyped for HLA-DRB1 and IL-10 and IL-6 alleles and results compared with the control population (n = 110). Hands and feet radiographs were taken at entry and then yearly during follow-up. The Larsen method was used to assess radiographic damage.
Results There were not differences in the distribution of IL-6 alleles in the RA patients compared with controls. A difference was found in the distribution of IL-10 polymorphism at position ?592 between patients with RA and the control population: 592CC, 592CA and 592AA were found in a 40%, 54% and 6% of patients with RA versus a 55%, 33% and 12% respectively among controls (p = 0.018). No other differences were found in the frequency of the IL-10 alleles between RA and controls. No associations related to IL-6 or IL-10 polymorphisms were found in relation to radiographic damage.
Conclusion The IL-10 polymorphism at position ?592 showed a greater proportion of the CA allele in AR compared with the control population, although the clinical implications if any of this difference remains to be determined. No IL-6 nor any other IL-10 polymorphisms either were found to be associated to RA. No IL-10 nor IL-6 polymorphisms were found to be related to erosive disease in early rheumatoid arthritis.
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