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SAT0196 Stereologic measurement of inflammatory synovial membrane volume on mr images
  1. A Savnik1,
  2. HS Thomsen2,
  3. JR Nyengaard3,
  4. H Bliddal1
  1. 1Parker Institute, University of Aarhus
  2. 2Radiology, Herlev University Hospital, Copenhagen
  3. 3Stereologic Research Laboratory, University of Aarhus, Aarhus, Denmark


Background Manual outlining of the synovial membrane on MR images in inflammatory joint diseases is too time consuming for clinical use.

Objectives The purpose was to introduce a less time-consuming stereologic method for measuring synovial volume by MRI in inflammatory joint diseases.

Methods Post-contrast 3-D T1-weighted turbo gradient MR images of the finger (metacarpophalangeal and interphalangeal) joints (14 joints) were acquired from 11 patients with rheumatoid arthritis (n = 8) and reactive arthritis (n = 3). Manually outlined volume was taken as a gold standard and compared with stereologic volume estimation on transverse 1 mm thick slices.

Results The total volume of 154 finger joints was estimated. A significant correlation between manual and stereologic estimations of synovial volumes was found (Spearman rho = 0.71, P = 0.002). 95% limits of agreement were ± 5–6 ml (14 finger joints per patient). The time used for volume determination in a patient varied from 1–2.5 h by manual outlining and from 0.5–1 h by stereologic determination.

Conclusion Stereologic volume estimation can provide measures of synovial volumes comparable to the manual outlining method and is less time-consuming. Stereologic volume estimation seems to be a clinically useful method, especially if it is integrated in the MR unit?s workstation.

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