We read with interest the article by O'Gradaigh and Merry on a comparison between low and high dose, and short and long acting corticosteroids in the treatment of carpal tunnel syndrome.1 We are skeptical of the conclusion drawn by the authors that low dose steroid is as effective as high dose or long acting preparations. We calculated the 95% confidence interval for each group: group A 66% (47 to 81%), group B 63% (44 to 79%), group C 5% (0.1 to 25%), group D 72% (47 to 90%), and group E 67% (43 to 85%). Owing to the small sample size, the reported response rate cannot reliably reflect the true response rate, as illustrated by the wide …