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Severe atherosclerotic changes, including aortic occlusion, associated with hyperhomocysteinaemia and antiphospholipid antibodies
  1. P E Spronka,
  2. E H Overboschb,
  3. N H Schuta
  1. aDepartment of Internal Medicine, Kennemer Gasthuis (EG), Haarlem, The Netherlands, bDepartment of Radiology
  1. Dr P E Spronk, Department of Intensive Care Medicine, ‘Onze lieve vrouwe gasthuis’, 1e Oosterparkstraat 279, 1091 HA Amsterdam, The Netherlandspspronk{at}wish.net

Abstract

Three patients are described with severe systemic atherosclerosis, including aortic occlusion, in the presence of a spectrum of risk factors, including hypercholesterolaemia, hypertension, a positive family history of cardiovascular problems, and hyperhomocysteinaemia. In all three patients high levels of anticardiolipin antibodies were found. The possible pathogenic role of antiphospholipid antibodies in atherosclerosis in the context of hyperhomocysteinaemia in these patients is discussed.

  • atherosclerosis
  • anticardiolipin antibodies
  • antiphospholipid antibodies
  • hyperhomocysteinaemia

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