Article Text

Download PDFPDF
Intravenous gammaglobulins in refractory polymyositis: lower dose for maintenance treatment is effective
  1. S Genevay,
  2. A Saudan-Kister,
  3. P-A Guerne
  1. Division of Rheumatology, Hôpital Universitaire, 26 Avenue Beau-Séjour, 1211 Genève 14 Switzerland
  1. Dr GuernePierre-Andre.Guerne{at}medecine.unige.ch

Abstract

OBJECTIVES To test lower dose immunoglobulins as a maintenance treatment in a patient with refractory polymyositis.

METHODS In a patient with longstanding refractory polymyositis, intravenous (IV) immunoglobulin treatment was introduced at a standard dose (2 g/kg monthly). After a few treatment courses, doses were reduced to 0.8 g/kg monthly, allowing perfusion over one single day.

RESULTS Although response to the standard dose was only partial, reduction of subsequent doses did not alter the evolution. On the contrary, the evolution was marked by further improvement, which has been sustained over the following year.

CONCLUSION Lower dose IV immunoglobulins as a maintenance treatment were used with excellent results in a case of refractory polymyositis allowing considerable reduction in treatment costs. Further trials should be undertaken to evaluate this interesting alternative.

  • intravenous immunoglobulin treatment
  • polymyositis

Statistics from Altmetric.com

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.