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Antiphospholipid antibodies and RA: presence of β2GP1 independent aCL
  1. C BONNET,
  2. P VERGNE,
  3. P BERTIN,
  1. Department of Rheumatology
  2. University of Limoges, France
  3. Department of Immunology
  4. University of Limoges, France
  1. Dr C Bonnet, Service de Rhumatologie, CHU Dupuytren, 2 Avenue Martin Luther-King, 87042 Limoges- France

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Anticardiolipin antibodies (aCL) are found in many conditions, such as lupus erythematosus, but also in other connective tissue diseases like rheumatoid arthritis (RA). To determine the prevalence and significance of aCL in RA, we evaluated the frequency of anticardiolipin and anti-β2 glycoprotein 1 (β2GP1) antibodies in patients with RA.

We studied serum samples from 50 consecutive patients (36 women, 14 men) with RA satisfying the 1987 American College of Rheumatology criteria for RA. Serum IgG and IgM aCL were characterised by enzyme linked immunosorbent assay (ELISA)1 using microtitration plates (Immunosorb, Nunc, Roksilde, Denmark) coated with cardiolipin purified from bovine heart (Sigma, St Louis, MO). Wells were saturated with 1% bovine serum albumin (BSA; Diamed, Cressier/Morat, …

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