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Incidence of RA in people with persistently raised RF
  1. Department of Medicine for the Elderly
  2. Tameside General Hospital
  3. Fountain Street
  4. Ashton under Lyne OL6 9RW, UK
  1. Department of Immunology
  2. National University Hospital
  3. Landspitalinn
  4. 101 Reykjavik
  5. Iceland

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A criticism of the study reported in theAnnals 1 is that age was not taken into account in the evaluation of the probability of development of rheumatoid arthritis (RA) among symptom free subjects with persistently raised rheumatoid factor (RF). The prevalence of RF can be as high as 14.1% in apparently healthy people aged 67–95 (mean age 81).2 RF is also 3.5 times more common in healthy elderly subjects (aged >65) than in their younger counterparts.3All these factors may alter the natural history of arthritis in elderly patients who have RF either in good health or in a non-arthritic presentation of RA.

The latter is exemplified by a patient admitted at the age of 76 with symptomatic, as well as echocardiographically validated rheumatoid pericarditis in the absence of arthritis. Rheumatoid arthritis latex fixation test (RA LFT) was positive with a titre of 1/160, antinuclear factor (ANF) titre was 1/250, and signs of active inflammatory disease included a platelet count of 750 × 109/l, and an erythrocyte sedimentation rate (ESR) of 98 mm/1st h (Westergren). Arthralgia of the hands and wrists developed for the first time two years later (when she was no longer taking steroids), with a subsequent RA LFT titre of 1/80 and an ANF titre of 1/320 about four months after the onset of arthralgia. Radiography showed narrowing of the joint spaces of the hands 12 months later, but there were as yet no erosions at this stage. Erosions were seen in March 1992, approximately two and a half years after the onset of arthralgia, when the RA LFT titre was 1/160, ANF titre 1/160, platelet count 421 × 109/l, ESR 18 mm/1st h. At her most recent attendance, on 2 February 2000, she was still very active, having continued to receive prednisolone (maximum dose 5 mg/d) continuously since 1989. Her only complaint was a little pain in the left thenar eminence and painful heels. RF was now 768 IU/ml, ANF titre 1/320, platelet count 340 × 109/l, ESR 42 mm/1st h. Antibodies against double stranded DNA had not been reported at any stage.


This case shows a remarkable dissociation between arthritic symptoms and levels of RF, perhaps signifying that when the immune status is altered in old age,2 the relation between RF and the natural history of RA might be less clear than it is in younger people.


Author's reply

It is certainly well documented that the incidence of raised rheumatoid factor (RF) increases with age. However, we are not aware of any study of different RF isotypes in this context, but our own unpublished observation indicates that it is mainly IgM RF that tends to increase in symptom free elderly people.

However, increased incidence of raised RF in elderly people is not relevant to the findings that we published recently in theAnnals.1-1 We simply observed increased prevalence and incidence of rheumatoid arthritis (RA) in elderly subjects who had one or more RF isotypes persistently raised, usually IgM and IgA, compared with those with a transient increase in RF or persistent increase in only one RF isotype. There was no significant age difference between these three groups of subjects studied.

Dr Jolobe's case history simply confirms what has already been often reported previously that an increase of RF often precedes clinical manifestation of RA.1-2 It would have been interesting to know about the RF isotype pattern of his patient. We have noted that the pulmonary manifestation of RA is strongly associated with raised IgA RF.1-3


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