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Yttrium radiosynoviorthesis in the treatment of knee arthritis in rheumatoid arthritis: a systematic review
  1. Liesbeth L J Heuft-Dorenboscha,
  2. Henrica C W de Vetb,
  3. Sjef van der Lindena
  1. aDepartment of Internal Medicine, Division of Rheumatology, University Hospital Maastricht, Maastricht, The Netherlands, bInstitute for Research in Extramural Medicine, Vrije Universiteit Amsterdam, The Netherlands
  1. Dr Liesbeth Heuft-Dorenbosch, Department of Internal Medicine, Division of Rheumatology, University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands Email: eheuf{at}


OBJECTIVE To consider the question: How strong is the evidence in favour of yttrium synovectomy in chronic knee arthritis in patients with rheumatoid arthritis in comparison with placebo and intra-articular steroid treatment?

METHODS A systematic review of the literature was performed using Medline and the Embase database.

RESULTS Initially, seven papers were identified, but only two met the inclusion criteria. Neither study showed evidence in favour of yttrium synovectomy.

CONCLUSION From the point of view of evidence based medicine it should be seriously questioned whether yttrium synovectomy deserves a place in clinical practice.

  • yttrium synovectomy
  • rheumatoid arthritis
  • systematic review
  • knee joint

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