Familial Mediterranean fever (FMF) is characterised by recurrent bouts of fever and peritonitis, pleuritis, arthritis or erysipelas-like skin disease. Between the episodes, FMF patients are free of symptoms and appear healthy.1 However, interestingly we observe leg complaints after prolonged standing or sitting, or both, in FMF patients, who usually experience these painful manifestations during evenings or after long distance bus trips. Thus we conducted a questionnaire study on 40 FMF patients (age, mean (SD); 21.6 (2.7) years; F: M, 2: 38) and 180 healthy male subjects (age, 21.3 (0.2) years) to ascertain the frequency of these complaints, and some of FMF patients were also included in a test to provoke these symptoms. Table 1 shows the questionnaire. Positive cases were also questioned for the presence of swelling or redness during these painful periods, and whether these complaints followed by an episode.

Although 14 of …