Response to methotrexate in early rheumatoid arthritis is associated with a decrease of T cell derived tumour necrosis factor α, increase of interleukin 10, and predicted by the initial concentration of interleukin 4

Martin Rudwaleit; Zhinan Yin; Stephanie Siegert; Martina Grolms; Andreas Radbruch; Jürgen Braun; Joachim Sieper

doi:10.1136/ard.59.4.311

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Response to methotrexate in early rheumatoid arthritis is associated with a decrease of T cell derived tumour necrosis factor α, increase of interleukin 10, and predicted by the initial concentration of interleukin 4

Online download statistics by month:

Online download statistics by month: March 2000 to March 2024

	Abstract	Full	Pdf
Mar 2000	26	32	12
Apr 2000	73	63	24
May 2000	11	32	10
Jun 2000	9	18	6
Jul 2000	2	19	15
Aug 2000	5	14	13
Sep 2000	2	8	4
Oct 2000	6	11	1
Nov 2000	8	8	6
Dec 2000	5	10	5
Jan 2001	5	12	4
Feb 2001	3	11	6
Mar 2001	1	9	8
Apr 2001	2	15	11
May 2001	2	11	4
Jun 2001	7	7	1
Jul 2001	4	13	6
Aug 2001	1	3	6
Sep 2001	3	5	3
Oct 2001	1	6	5
Nov 2001	0	3	0
Dec 2001	2	2	1
Jan 2002	1	5	6
Feb 2002	0	4	6
Mar 2002	4	4	2
Apr 2002	3	8	0
May 2002	1	4	1
Jun 2002	3	4	7
Jul 2002	3	9	2
Aug 2002	2	3	5
Sep 2002	1	9	4
Oct 2002	1	2	0
Nov 2002	0	6	2
Dec 2002	1	11	9
Jan 2003	3	7	3
Feb 2003	3	11	10
Mar 2003	0	8	2
Apr 2003	6	13	8
May 2003	2	5	9
Jun 2003	2	3	4
Jul 2003	16	51	6
Aug 2003	12	5	2
Sep 2003	9	11	2
Oct 2003	7	34	5
Nov 2003	8	28	1
Dec 2003	10	14	4
Jan 2004	15	57	10
Feb 2004	8	18	0
Mar 2004	13	19	3
Apr 2004	16	21	6
May 2004	35	37	0
Jun 2004	49	44	6
Jul 2004	43	44	6
Aug 2004	41	36	8
Sep 2004	27	28	4
Oct 2004	17	34	12
Nov 2004	13	22	7
Dec 2004	9	18	8
Jan 2005	13	23	8
Feb 2005	9	17	6
Mar 2005	11	28	8
Apr 2005	7	14	10
May 2005	6	22	12
Jun 2005	2	12	11
Jul 2005	6	30	13
Aug 2005	7	13	11
Sep 2005	5	10	2
Oct 2005	12	15	9
Nov 2005	10	14	5
Dec 2005	1	4	4
Jan 2006	2	14	9
Feb 2006	6	16	9
Mar 2006	1	12	8
Apr 2006	3	12	3
May 2006	4	5	6
Jun 2006	2	4	3
Jul 2006	2	7	8
Aug 2006	2	6	4
Sep 2006	1	10	7
Oct 2006	5	15	9
Nov 2006	9	24	10
Dec 2006	9	15	8
Jan 2007	2	20	9
Feb 2007	5	32	13
Mar 2007	7	14	4
Apr 2007	4	7	7
May 2007	11	2	4
Jun 2007	10	1	1
Jul 2007	6	5	1
Aug 2007	11	0	2
Sep 2007	8	3	3
Oct 2007	6	2	0
Nov 2007	11	7	6
Dec 2007	9	2	2
Jan 2008	9	5	4
Feb 2008	8	0	0
Mar 2008	19	4	6
Apr 2008	12	1	0
May 2008	25	4	3
Jun 2008	16	0	0
Jul 2008	19	0	1
Aug 2008	71	1	0
Sep 2008	91	3	0
Oct 2008	54	2	4
Nov 2008	23	1	1
Dec 2008	5	1	1
Jan 2009	7	3	2
Feb 2009	6	3	8
Mar 2009	33	1	2
Apr 2009	9	1	0
May 2009	7	1	2
Jun 2009	7	1	2
Jul 2009	6	0	1
Aug 2009	3	0	1
Sep 2009	17	1	1
Oct 2009	27	4	4
Nov 2009	8	0	0
Dec 2009	9	0	7
Jan 2010	17	6	2
Feb 2010	4	0	2
Mar 2010	3	2	1
Apr 2010	2	2	0
May 2010	5	2	1
Jun 2010	16	2	7
Jul 2010	16	1	2
Aug 2010	2	2	1
Sep 2010	1	4	8
Oct 2010	7	4	1
Nov 2010	4	2	1
Dec 2010	4	6	3
Jan 2011	5	0	0
Feb 2011	6	4	5
Mar 2011	9	0	2
Apr 2011	4	2	6
May 2011	4	1	2
Jun 2011	6	1	2
Jul 2011	9	2	1
Aug 2011	6	1	3
Sep 2011	2	2	3
Oct 2011	9	3	0
Nov 2011	8	4	1
Dec 2011	6	9	5
Jan 2012	15	11	5
Feb 2012	11	5	3
Mar 2012	14	4	6
Apr 2012	12	6	8
May 2012	15	6	5
Jun 2012	11	4	7
Jul 2012	22	6	7
Aug 2012	12	8	15
Sep 2012	18	9	13
Oct 2012	9	7	11
Nov 2012	17	8	9
Dec 2012	12	6	7
Jan 2013	18	15	13
Feb 2013	15	5	7
Mar 2013	24	10	9
Apr 2013	16	14	7
May 2013	17	11	10
Jun 2013	5	5	6
Jul 2013	6	5	7
Aug 2013	11	6	8
Sep 2013	9	4	7
Oct 2013	7	5	7
Nov 2013	6	5	3
Dec 2013	12	4	4
Jan 2014	13	6	9
Feb 2014	4	8	6
Mar 2014	18	9	4
Apr 2014	12	7	3
May 2014	17	13	6
Jun 2014	12	5	2
Jul 2014	18	10	3
Aug 2014	9	4	4
Sep 2014	6	5	6
Oct 2014	4	4	1
Nov 2014	10	4	2
Dec 2014	12	12	7
Jan 2015	13	5	5
Feb 2015	2	0	3
Mar 2015	21	2	5
Apr 2015	4	5	7
May 2015	3	7	2
Jun 2015	7	2	2
Jul 2015	4	3	2
Aug 2015	5	3	1
Sep 2015	16	3	2
Oct 2015	6	4	5
Nov 2015	3	3	5
Dec 2015	10	4	3
Jan 2016	9	2	3
Feb 2016	18	2	4
Mar 2016	11	3	5
Apr 2016	9	2	11
May 2016	9	3	11
Jun 2016	7	4	10
Jul 2016	4	4	2
Aug 2016	5	0	1
Sep 2016	16	3	3
Oct 2016	9	6	2
Nov 2016	11	5	3
Dec 2016	10	2	2
Jan 2017	10	5	4
Feb 2017	2	3	1
Mar 2017	2	15	3
Apr 2017	1	6	0
May 2017	0	6	0
Jun 2017	3	10	2
Jul 2017	16	15	12
Aug 2017	18	12	2
Sep 2017	22	14	7
Oct 2017	23	19	0
Nov 2017	22	20	8
Dec 2017	12	10	2
Jan 2018	16	6	8
Feb 2018	15	9	6
Mar 2018	10	8	3
Apr 2018	12	10	4
May 2018	26	16	4
Jun 2018	43	29	7
Jul 2018	15	15	6
Aug 2018	38	18	6
Sep 2018	22	22	2
Oct 2018	35	29	1
Nov 2018	24	24	7
Dec 2018	35	31	1
Jan 2019	31	16	3
Feb 2019	19	16	1
Mar 2019	15	13	7
Apr 2019	8	4	11
May 2019	8	6	8
Jun 2019	4	4	7
Jul 2019	7	7	3
Aug 2019	8	6	6
Sep 2019	4	2	5
Oct 2019	5	5	6
Nov 2019	6	6	3
Dec 2019	4	4	7
Jan 2020	10	8	8
Feb 2020	6	6	4
Mar 2020	4	4	5
Apr 2020	6	4	4
May 2020	11	9	6
Jun 2020	16	10	5
Jul 2020	16	15	8
Aug 2020	5	5	6
Sep 2020	14	14	4
Oct 2020	6	4	1
Nov 2020	6	2	8
Dec 2020	8	8	2
Jan 2021	13	5	10
Feb 2021	22	9	9
Mar 2021	10	6	3
Apr 2021	15	3	8
May 2021	8	6	3
Jun 2021	7	7	3
Jul 2021	9	9	5
Aug 2021	6	6	5
Sep 2021	3	3	1
Oct 2021	9	8	16
Nov 2021	19	11	21
Dec 2021	2	2	3
Jan 2022	15	9	5
Feb 2022	8	6	2
Mar 2022	12	8	9
Apr 2022	22	12	5
May 2022	31	27	10
Jun 2022	26	22	10
Jul 2022	20	18	3
Aug 2022	42	34	7
Sep 2022	39	34	13
Oct 2022	31	27	7
Nov 2022	24	22	12
Dec 2022	14	14	2
Jan 2023	30	24	5
Feb 2023	50	48	3
Mar 2023	17	15	3
Apr 2023	16	8	12
May 2023	19	17	6
Jun 2023	20	14	2
Jul 2023	21	15	6
Aug 2023	14	13	5
Sep 2023	35	15	6
Oct 2023	16	12	7
Nov 2023	16	14	12
Dec 2023	83	16	2
Jan 2024	50	5	1
Feb 2024	34	2	3
Mar 2024	275	2	0
Total	3846	2876	1470

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