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Circulating concentrations of soluble L-selectin (CD62L) in patients with primary Sjögren's syndrome
  1. Mario García-Carrascoa,d,
  2. Pilar Pizcuetab,
  3. Ricard Cerveraa,
  4. Manuel Ramos-Casalsa,
  5. Antoni Sisóa,
  6. Gloria de la Reda,
  7. Miguel Ingelmoa,
  8. Josep Fonta,
  9. Pablo Engelc
  1. aSystemic Autoimmune Diseases Unit, Department of Medicine, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Hospital Clínic, School of Medicine, University of Barcelona, Barcelona, Catalonia, Spain, bHepatic Haemodynamic Laboratory, Liver Unit, cImmunology Unit, Department of Cellular Biology and Pathology, dDepartment of Rheumatology, Denernévita Universidad Autonoma de Puebla, Puebla, Maxico
  1. Dr Font, Unitat de Malalties Autoimmunes Sistèmiques, Hospital Clínic, C/Villarroel, 170, 08036-Barcelona, Catalonia, Spain

Abstract

OBJECTIVE Serum concentrations of soluble (s) L-selectin (CD62L) were measured in patients with primary Sjögren's syndrome (SS) to relate these concentrations to clinical and immunological features of SS.

METHODS The study included 40 consecutive patients (38 women and two men) with a mean age of 61 years (range 24–78) who fulfilled four or more of the preliminary diagnostic criteria for SS proposed by the European Community Study Group in 1993, and 33 healthy blood donors from the hospital blood bank. A sandwich enzyme linked immunosorbent assay (ELISA) was used to detect the soluble form of human sL-selectin (CD62L).

RESULTS The mean (SEM) values of sL-selectin (CD62L) were 861 (66) μg/ml for patients with SS and 986 (180) μg/ml for healthy blood donors, but there was no significant difference. In patients with primary SS, serum sL-selectin (CD62L) concentrations were significantly higher in patients with Raynaud's phenomenon (1275 (112) μg/ml versus 789 (69) μg/ml, p=0.007), autoimmune thyroiditis (1162 (113) μg/ml versus 787 (69) μg/ml, p=0.02) and rheumatoid factor (993 (95) μg/ml versus 684 (70) μg/ml, p=0.01) when compared with patients without these features.

CONCLUSION The presence of Raynaud's phenomenon, autoimmune thyroiditis and rheumatoid factor is associated with higher concentrations of circulating sL-selectin (CD62L) in the sera of patients with primary SS.

  • soluble adhesion molecules
  • L-selectin
  • primary Sjögren's syndrome

https://doi.org/10.1136/ard.59.4.297

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