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Magnitude of the genetic component in juvenile idiopathic arthritis
  1. A SAVOLAINEN,
  2. H SÄILÄ,
  3. K KOTANIEMI
  1. O KAIPIAINEN-SEPPÄNEN
  1. M LEIRISALO-REPO
  1. K AHO
  1. Rheumatism Foundation Hospital
  2. Heinola, Finland
  3. Department of Medicine
  4. Kuopio University Hospital
  5. Kuopio, Finland
  6. Department of Medicine
  7. Division of Rheumatology
  8. Helsinki University Central Hospital
  9. Helsinki, Finland
  10. National Public Health Institute
  11. Helsinki, Finland
  1. Dr A Savolainen, Rheumatism Foundation Hospital, 18120 Heinola, Finland

https://doi.org/10.1136/ard.59.12.1001

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    Genetic factors undoubtedly play a part at least in some forms of juvenile idiopathic arthritis (JIA). Yet it is commonly believed that the risk to a sibling of a patient with JIA is not particularly strong as shown by the rarity of reported multicase families.1

    Multicase JIA families have been traced systematically at the Rheumatism Foundation Hospital in Heinola, Finland, over a period of 15 years. A total of 41 families with 88 affected siblings (34 boys, 54 girls) were found fulfilling the Durban criteria for JIA.2In 60 (68%) of these 88 patients the disease was pauciarticular …

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