Leflunomide: mode of action in the treatment of rheumatoid arthritis

F C Breedveld; J-M Dayer

doi:10.1136/ard.59.11.841

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Leflunomide: mode of action in the treatment of rheumatoid arthritis

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	Abstract	Full	Pdf
Oct 2000	100	117	50
Nov 2000	421	497	133
Dec 2000	91	107	31
Jan 2001	26	68	30
Feb 2001	15	50	28
Mar 2001	20	77	27
Apr 2001	29	70	25
May 2001	56	69	21
Jun 2001	96	57	14
Jul 2001	20	43	24
Aug 2001	11	39	14
Sep 2001	25	69	9
Oct 2001	25	85	24
Nov 2001	30	58	19
Dec 2001	13	25	12
Jan 2002	25	44	16
Feb 2002	11	54	20
Mar 2002	17	38	19
Apr 2002	24	30	15
May 2002	16	37	15
Jun 2002	9	34	15
Jul 2002	18	53	19
Aug 2002	6	26	15
Sep 2002	3	34	14
Oct 2002	6	40	23
Nov 2002	4	37	21
Dec 2002	5	27	13
Jan 2003	4	44	14
Feb 2003	2	22	13
Mar 2003	4	35	9
Apr 2003	16	25	17
May 2003	6	34	14
Jun 2003	10	30	10
Jul 2003	11	48	11
Aug 2003	13	31	20
Sep 2003	15	35	20
Oct 2003	23	72	19
Nov 2003	28	38	10
Dec 2003	27	63	16
Jan 2004	26	76	16
Feb 2004	25	41	23
Mar 2004	20	42	22
Apr 2004	26	37	18
May 2004	64	86	43
Jun 2004	61	111	46
Jul 2004	53	82	25
Aug 2004	41	91	28
Sep 2004	32	76	36
Oct 2004	20	92	22
Nov 2004	32	113	37
Dec 2004	21	95	30
Jan 2005	35	82	40
Feb 2005	23	111	34
Mar 2005	43	111	54
Apr 2005	15	81	41
May 2005	15	62	23
Jun 2005	25	42	21
Jul 2005	23	74	27
Aug 2005	21	65	27
Sep 2005	22	72	27
Oct 2005	23	94	40
Nov 2005	20	115	35
Dec 2005	13	67	32
Jan 2006	10	56	20
Feb 2006	24	65	27
Mar 2006	14	97	21
Apr 2006	23	67	32
May 2006	29	55	28
Jun 2006	33	25	21
Jul 2006	21	43	21
Aug 2006	35	45	19
Sep 2006	30	61	35
Oct 2006	32	86	53
Nov 2006	34	80	48
Dec 2006	25	67	34
Jan 2007	22	68	42
Feb 2007	33	114	34
Mar 2007	34	70	53
Apr 2007	39	27	16
May 2007	51	44	22
Jun 2007	32	16	13
Jul 2007	32	21	15
Aug 2007	23	22	14
Sep 2007	26	12	13
Oct 2007	34	15	19
Nov 2007	38	13	16
Dec 2007	28	8	19
Jan 2008	22	16	11
Feb 2008	35	9	9
Mar 2008	27	11	15
Apr 2008	35	10	12
May 2008	56	11	17
Jun 2008	23	7	10
Jul 2008	35	6	8
Aug 2008	42	2	4
Sep 2008	56	2	8
Oct 2008	47	4	5
Nov 2008	35	3	4
Dec 2008	24	3	7
Jan 2009	22	7	9
Feb 2009	28	11	6
Mar 2009	67	18	15
Apr 2009	44	6	18
May 2009	48	19	16
Jun 2009	36	7	10
Jul 2009	42	4	15
Aug 2009	49	13	11
Sep 2009	36	9	10
Oct 2009	42	13	4
Nov 2009	50	6	6
Dec 2009	39	3	12
Jan 2010	46	8	6
Feb 2010	37	1	5
Mar 2010	38	13	16
Apr 2010	53	12	8
May 2010	42	16	7
Jun 2010	44	18	19
Jul 2010	39	8	15
Aug 2010	72	36	10
Sep 2010	61	37	7
Oct 2010	86	45	16
Nov 2010	97	41	6
Dec 2010	57	14	7
Jan 2011	108	20	6
Feb 2011	99	37	17
Mar 2011	113	39	12
Apr 2011	69	27	10
May 2011	145	42	7
Jun 2011	70	19	12
Jul 2011	75	26	5
Aug 2011	73	12	5
Sep 2011	83	42	13
Oct 2011	123	37	10
Nov 2011	109	93	20
Dec 2011	39	123	34
Jan 2012	31	147	25
Feb 2012	33	106	35
Mar 2012	44	110	21
Apr 2012	37	180	24
May 2012	54	194	48
Jun 2012	24	180	20
Jul 2012	31	195	33
Aug 2012	18	142	39
Sep 2012	35	172	33
Oct 2012	41	148	36
Nov 2012	44	144	34
Dec 2012	45	62	39
Jan 2013	45	71	48
Feb 2013	40	63	40
Mar 2013	40	66	29
Apr 2013	47	90	37
May 2013	28	96	37
Jun 2013	24	42	21
Jul 2013	28	58	24
Aug 2013	33	46	12
Sep 2013	40	57	23
Oct 2013	49	53	15
Nov 2013	59	81	27
Dec 2013	41	41	705
Jan 2014	27	54	29
Feb 2014	31	49	20
Mar 2014	47	75	19
Apr 2014	73	59	16
May 2014	64	69	25
Jun 2014	41	48	12
Jul 2014	49	54	20
Aug 2014	17	48	18
Sep 2014	36	45	12
Oct 2014	58	65	34
Nov 2014	60	77	16
Dec 2014	37	46	21
Jan 2015	35	37	13
Feb 2015	40	28	19
Mar 2015	32	39	19
Apr 2015	73	33	17
May 2015	35	33	28
Jun 2015	34	41	18
Jul 2015	29	47	19
Aug 2015	30	39	25
Sep 2015	45	39	16
Oct 2015	70	42	19
Nov 2015	42	32	13
Dec 2015	40	26	12
Jan 2016	53	30	11
Feb 2016	33	25	8
Mar 2016	114	33	24
Apr 2016	47	56	23
May 2016	31	22	10
Jun 2016	42	31	18
Jul 2016	46	33	22
Aug 2016	38	35	22
Sep 2016	52	77	35
Oct 2016	46	41	22
Nov 2016	37	50	25
Dec 2016	33	40	12
Jan 2017	36	41	11
Feb 2017	21	33	16
Mar 2017	26	49	12
Apr 2017	18	93	15
May 2017	19	70	16
Jun 2017	31	62	18
Jul 2017	113	83	26
Aug 2017	102	62	14
Sep 2017	112	66	18
Oct 2017	113	65	20
Nov 2017	137	81	14
Dec 2017	76	54	17
Jan 2018	105	61	33
Feb 2018	102	56	22
Mar 2018	138	76	25
Apr 2018	96	32	25
May 2018	70	44	10
Jun 2018	98	76	21
Jul 2018	114	92	27
Aug 2018	127	91	25
Sep 2018	92	80	30
Oct 2018	206	181	38
Nov 2018	181	139	42
Dec 2018	117	101	13
Jan 2019	120	105	17
Feb 2019	223	207	20
Mar 2019	180	136	42
Apr 2019	131	104	43
May 2019	95	69	28
Jun 2019	110	92	23
Jul 2019	126	94	39
Aug 2019	157	125	29
Sep 2019	156	139	36
Oct 2019	180	156	53
Nov 2019	116	102	32
Dec 2019	113	97	27
Jan 2020	175	158	35
Feb 2020	298	280	43
Mar 2020	156	138	60
Apr 2020	161	136	73
May 2020	150	114	51
Jun 2020	108	92	55
Jul 2020	100	92	15
Aug 2020	97	77	36
Sep 2020	142	122	25
Oct 2020	156	143	71
Nov 2020	166	153	47
Dec 2020	225	213	54
Jan 2021	201	189	51
Feb 2021	209	202	39
Mar 2021	200	182	56
Apr 2021	218	196	48
May 2021	268	265	36
Jun 2021	201	201	46
Jul 2021	237	237	42
Aug 2021	222	221	35
Sep 2021	433	433	31
Oct 2021	283	275	36
Nov 2021	305	288	34
Dec 2021	325	324	26
Jan 2022	290	264	52
Feb 2022	237	230	50
Mar 2022	434	411	68
Apr 2022	406	379	40
May 2022	392	369	45
Jun 2022	375	359	50
Jul 2022	882	871	41
Total	19937	21393	7121

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