Article Text

Download PDFPDF

No serological indications that systemic lupus erythematosus is linked with exposure to human parvovirus B19
  1. Anders Bengtssona,
  2. Anders Widellb,
  3. Sölve Elmståhlc,
  4. Gunnar Sturfelta
  1. aDepartment of Rheumatology, University Hospital, Lund, Sweden, bDepartment of Clinical Microbiology, University Hospital, Malmö, Sweden, cDepartment of Community Medicine, University Hospital, Malmö
  1. Dr A Bengtsson, Department of Rheumatology, Lund University Hospital, S-221 85 Lund, Sweden


OBJECTIVES Infectious agents like parvovirus have been implicated as exogenous factors that could trigger onset of systemic lupus erythematosus (SLE). A number of case reports describing a SLE-like presentation of acute human parvovirus B19 infection have been published, but no systematic investigation of the actual seroprevalence in epidemiologically defined SLE populations has previously been reported.

METHODS Sera from 99 SLE patients from a defined area in Southern Sweden, representing 88% of all new SLE cases 1981–1995 within the Lund-Orup Health Care district with 175 000 adult inhabitants (> 15 years of age), and sera from 99 age and sex matched healthy controls were investigated for the presence of IgG parvovirus antibodies. Two different commercially available EIA kits were used; one using E coli synthesised parvovirus VP1/VP2 antigen, and one using baculovirus derived parvovirus VP2 antigen.

RESULTS The EIA using baculovirus derived antigen was more sensitive and surprisingly the controls were more often positive than the SLE patients were (79% versus 65%, χ2 p=0.027). No difference between the groups was seen with the EIA using E coliderived antigen (46% versus 49%). Titration experiments indicated that the discordance between the two tests was a matter of sensitivity rather than specificity.

CONCLUSION No evidence was found of human parvovirus B19 infection being more prevalent among SLE patients. On the contrary, in one of the parvovirus EIAs the controls were more often positive than the SLE patients were.

  • parvovirus
  • systemic lupus erythematosus
  • viral infection
  • autoantibodies
View Full Text

Statistics from


    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.