Dr Hohler and colleagues1 have examined LMP2 polymorphisms and extraspinal manifestations in spondyloarthropathies arriving at the conclusion that there is no independent association between LMP2 genotypes and the occurrence of uveitis in HLA-B27 positive subjects when stratified for HLA DR. In my view, this study lacks sufficient power to decide this question definitively. Careful analysis of DR4 positive subjects from the data provided in table 1 of their report shows that 81.25% of patients with acute anterior uveitis carry the LMP2 BB genotype compared with 62.5% of B27 positive controls and 61.5% of spondyloarthropathy patients with axial disease only. This suggests that LMP2 may contribute independently of DR4 to the development of uveitis, though small numbers of DR4 positive patients and controls (eight B27 positive controls, 16 spondyloarthropathy patients with acute anterior uveitis and 26 patients with axial disease only) do not permit statistically significant conclusions. Table 1 summarises our current …