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Polyarthritis and pitting oedema
    1. Jean Dudler,
    2. Jean-Charles Gerster,
    3. Alexander So
    1. Service de Rhumatologie, Médecine Physique et Rééducation, Centre Hospitalier Universitaire Vaudois, CHUV - 1011 Lausanne, Switzerland
    1. Dr J Dudler.

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    Case history

    CASE 1

    A 74 year old white man presented with an abrupt onset of metacarpophalangeal (MCP) and interphalangeal (IP) joint pains associated with swelling of both hands. He had two hours of morning stiffness but no other joint complaints or history of constitutional symptoms. Past medical history was unremarkable except for diabetes mellitus type 2 treated with oral antidiabetic drugs.

    Key points

    • RS3PE is a definite subset of the seronegative symmetrical polyarthritis of the aged characterised by dramatic pitting oedema of the hands, male predominance, old age, exquisite response to corticosteroids, and long term remission after withdrawal.

    • RS3PE may be part of a paraneoplastic syndrome and heightened suspicion for underlying malignancy is important, especially if the response to corticosteroids is poor.

    • The differential diagnosis of arthritis that presents with prominent peripheral oedema needs to be considered before making a diagnosis.

    Examination showed gross pitting oedema of the dorsum of both hands with swollen and tender MCPs, severe tenosynovitis of the flexor tendons, and swollen and limited wrist movements. Both knees had painless small effusions. Other joints showed no signs of inflammation and no nodules were palpated.

    The erythrocyte sedimentation rate was increased at 55 mm in the first hour. Except for a mild inflammatory anaemia and hyperglycaemia between 8 to 10 mmol/l, the full blood count, renal, liver and thyroid function tests were within normal limits. Electrophoresis demonstrated an acute and subacute inflammatory pattern without monoclonal peak and rheumatoid factor and ANA were negative. Four millilitres of clear synovial fluid were aspirated from the left knee. Cell count was 198/mm3 with no crystals.

    The patient was treated with prednisone with a rapid clinical response. Maximal dose was 20 mg per day, slowly tapered over four months to zero. No flare up was observed and after two years the patient was still asymptomatic and his sedimentation rate normal.

    CASE 2

    A 86 year old white man presented with a three week history of severe swelling of the right hand associated with pain and morning stiffness. Except for slight paresthesia in the hand, he had no other complaint. Past medical history was unremarkable.

    Examination demonstrated severe pitting oedema of the dorsum of the right hand with swollen and tender MCPs (fig 1). The wrist was also swollen and limited with discrete signs of a carpal tunnel syndrome. The left wrist and one MCP joint were painful to palpation.

    Figure 1

    Severe pitting oedema of the dorsum of the hand.

    The erythrocyte sedimentation rate was 24 mm in the first hour and C reactive protein was 27 mg/ml. Rheumatoid factor was negative. Arthrocentesis of the right wrist showed 750 leucocytes per mm3 with no crystals.

    The patient was treated with 15 mg of prednisone per day. Clinical response was rapid and the corticosteroids were tapered over the next 10 months without a flare up. Non-specific chronic synovitis was demonstrated on synovial biopsy at carpal tunnel release three months after the onset of the disease

    CASE 3

    A 78 year old white man suddenly developed pain and severe oedema of both hands. He also complained of shoulders, hips and knees pain with morning stiffness lasting 45 minutes. Diabetes mellitus and peripheral vascular disease were noted on past medical history, but no previous osteoarticular complaints.

    On examination, diffuse oedema of both hands was present and the wrists were painful and very limited in mobility. Active mobilisation of the shoulder was also painful and limited. Effusions were present in both knees and no nodules were palpated.

    The erythrocyte sedimentation rate was increased at 64 mm in the first hour and C reactive protein at 88 mg/ml. Except for a discrete inflammatory anaemia (114 g/l) and hyperglycaemia (between 9 and 12 mmol/l), renal and thyroid function tests were normal. There was a moderate increase in alkaline phosphatase at 181 U/l (normal 36–108) associated with increased γ-glutamyltransferase (72 U/l, normal 11–62). Rheumatoid factor was negative and ANA slightly positive, speckled at 1/320. Ten millilitres of clear synovial fluid were aspirated from the right knee. Cell count was 6800/mm3 and no crystals were demonstrated. Radiography demonstrated degenerative changes in IPD joints, but no erosion or calcification.

    Prednisone 15 mg daily was introduced with complete remission of pain and oedema.

    Eight months later, the patient was rehospitalised for severe inflammatory lumbar pain. There was no residual complaints at the level of the hands or the shoulders then, but the patient had lost 5 kg. Alkaline phosphatase was now highly increased at 2740 U/l with no change in γ-glutamyltransferase activities (70 U/l). Bone scintigraph demonstrated multiple metastases in the vertebrae, pelvis, sacrum, clavicles, cranium and femurs from a biopsy confirmed prostatic adenocarcinoma. The patient died a few days later from pneumonia.



    The association of pitting oedema and arthritis of the hands is fairly rare and specific. It is very suggestive of a subset of the seronegative polyarthritides of the elderly, the RS3PE syndrome or “remitting seronegative symmetrical synovitis with pitting edema”, as initially described by McCarty in 1985.1 He isolated, from the heterogeneous group of elderly patients with polyarthritis, a subgroup of 10 patients all fulfilling the ARA (American Rheumatism Association) criteria for rheumatoid arthritis but who presented a distinctive clinical picture and evolution. The principal characteristics reported by McCarty in this seminal paper were confirmed in a latter paper of 13 additional cases2 and in numerous reports in the literature.3-7 Typically, as in our cases, patients are elderly white people (average >70, range 45 to 92) with a male predominance of about 3:1. Onset is rapid, in less than a month, often even explosive with patients able to pinpoint it to within a few hours. They note the simultaneous apparition of pain and symmetrical pitting oedema of the back of the hands. Pain involves the wrist, the MCPs and IPs as well as the flexor tendon sheaths of the fingers. Shoulder girdle pain is also frequently reported, contrasting with the rarity of symptoms from the pelvic girdle. Fever and asthenia are also occasionally present.

    The clinical picture is characterised by a florid pitting oedema of the dorsum of the hands, which may also be present in the feet. There is always an important limitation of the wrists and, very often, small effusions of the knees are reported. Magnetic resonance imaging studies have demonstrated severe extensor tenosynovitis believed to be the principal lesion responsible for the oedema.8 In contrast, lymphoscintigraphy studies showed no reduction of axillary lymphnode radioactivity, indicating normal lymphatic function.8

    Laboratory tests typically demonstrate an inflammatory state with increased sedimentation rate and C reactive protein, discrete inflammatory anaemia and hypoalbuminaemia. Rheumatoid factor is negative. In cases where synovial fluid analyses were carried out, leucocyte counts were usually lower than in rheumatoid arthritis and in our cases, the values 198, 750, and 6800/mm3 are typical.

    Radiography of the hands and wrists show soft tissue oedema and generalised osteopenia. Bone erosions are absent.

    Crucial for the definition of the syndrome, functional prognosis is excellent. Duration of treatment is usually less than a year and, in almost all cases reported, complete and sustained remission was obtained even after withdrawal of medication. Treatments used vary widely: from non-steroidal anti-inflammatory drugs (NSAIDs) to salicylates, antimalarials, gold salts, and corticosteroids. Low dose prednisone (10 to 15 mg/day) was found to be effective with a rapid and spectacular effect, while response rate was variable and slower with other treatments. Again, long term functional prognosis is excellent, except for a small persisting limitation of the wrists or the fingers.

    The aetiology of the syndrome is still unknown. The clustering of patients from rural areas and the seasonal variation, with peaks in summer and autumn, initially suggested to McCarty an infectious or para-infectious origin.1 Nevertheless, serological studies for Borrelia burgdorferi remained negative and epidemiological case-control studies did not show any special exposition to an infectious or toxic agent.2 A search for a retroviral aetiology has also been negative.9 Finally, McCarty reported an increased prevalence of HLA B7, found in 15 of 23 patients (59%) compared with 24% in a control white population (relative risk 4.4).2 Even if this finding has not been confirmed by other groups, this tends to distinguish RS3PE as a specific entity apart from rheumatoid arthritis and other seronegative polyarthritides of the elderly.

    As always the case in medicine, RS3PE can present atypically. Asymmetrical cases, like case number 2, have been reported. Two were in patients with neurological disease (longstanding hemiparesis),10 similar to that reported in rheumatoid arthritis, and one without neurological involvement.11Three cases, typical but for their young age (30 years of age in average) have also been reported.


    RS3PE syndrome has, by definition, a good prognosis. Nevertheless, there have been reports of apparently classic RS3PE syndromes that were complicated by connective tissue diseases such as polyarteritis nodosa12 or other vasculitides.13 Pitting oedema typical of RS3PE was reported in lupus,14 ankylosing spondylitis,15 and temporal arteritis.16 A prospective study looked at pitting oedema of the hands as a prognostic factor in various subsets of late onset rheumatoid arthritis (RS3PE, seropositive cases, cases with erosions or who relapsed after corticosteroids withdrawal).17 Interestingly, pitting oedema was found to be an independent factor (from the diagnosis of RS3PE) identifying, at onset, a favourable outcome in elderly patients with polyarthritis.17

    RS3PE syndrome has also recently emerged as a potential paraneoplastic syndrome. Cases of gastric carcinoma,18 endometrial carcinoma,19 and pancreatic carcinoma20 have been reported in association with RS3PE. In all cases, complete remission was observed after resection of the tumour, indicating a true paraneoplastic syndrome. Our case number 3 is representative of such patient. A confident diagnosis of a paraneoplastic syndrome could not be reached as the tumour was too advanced for specific treatment. In this older population, chance concurrence of both diseases could not be excluded, but such examples emphasise the need for a thorough examination in elderly patients with RS3PE syndrome, and heightened suspicion of potential underlying malignant diseases, especially if the response to corticosteroids is mitigated.

    Finally, two of our patients had diabetes mellitus. No specific association of RS3PE with diabetes has been reported and this represents most probably the coincidence with a common comorbidity in the elderly population.


    The association of arthritis and oedema of the hands is fairly unusual and should lead us to consider certain diagnoses when confronted by such cases. RS3PE is not the sole diagnosis and a list of other differential diagnoses, with some helpful clinical features and investigations to establish the diagnostic, are discussed and summarised in table 1.

    Table 1

    Differential diagnosis of oedema and arthritis of the hands

    Mixed connective tissue disease (Sharp syndrome)

    Oedema of the hands, particularly the fingers with a sausage-like appearance, associated to a thickened, tightened and inelastic skin was present in 88% of the initial cases reported by Sharp21 and is still a main criteria in all the diagnosis criteria sets in use.22 Typically, and unlike RS3PE, patients will be young (average age 36), female (84%), and suffering from Raynaud phenomena (84%). They may also demonstrate ulcerations or erythematous lesions suggestive of dermatopolymyositis. Finally, presence of high titre speckled ANA with U1-RNP specificity, the hallmark of this syndrome, will allow this diagnosis to be made.

    CPPD (chondrocalcinosis)

    In the elderly, CPPD can also be associated with oedema of the dorsum of the hands and acute or subacute inflammatory state (fig 2). Asymmetric oedema, female sex, and absence or little constitutional symptoms (although C reactive protein and sedimentation rate can be increased) all favour this diagnosis. Radiography and analysis of the synovial fluid under polarised light should establish the correct diagnosis. A rapid and favourable response to NSAIDs alone is also helpful.

    Figure 2

    Abrupt onset of oedema and pain of the left hand in an 80 year old women secondary to a chondrocalcinosis crisis confirmed by arthrocentesis and radiography.

    Reflex sympathetic dystrophy (Sudeck’s disease, algodystrophy)

    Oedema of the hands can be the presentation of reflex sympathetic dystrophy that may be bilateral. Exquisite pain aggravated by active and passive mobilisation, vasomotor and skin alterations, absence of true arthritis, presence of predisposing factor such as myocardial infarction, stroke or use of barbiturates, and the absence of systemic inflammation will generally lead to the correct diagnosis.23 Radiography, bone scintigraphy, and magnetic resonance imaging can be useful but are not specific for diagnostic.

    Amyloid arthropathy

    Puffy hands have been described in amyloid arthropathy. It is rare, almost exclusively from the AL type and generally associated with light chain multiple myeloma.24 ,25 The involvement is better described as a pseudo-oedema as it is not or only slightly inflammatory and abnormally firm on palpation. The onset is typically insidious and morning stiffness rare and brief. The evolution is progressive and extra-articular symptoms are related to the polyvisceral involvement, which will appear at onset or during evolution (particularly kidney involvement with proteinuria). Immunofixation and demonstration of the specific birefringence with Congo Red on a biopsy or synovial fluid (free amyloid debris) will lead to the correct diagnosis.

    Psoriatic arthritis and Reiter’s syndrome

    Diagnosis is not difficult but one should be aware that spondyloarthropathies, especially psoriatic arthritis or Reiter’s syndrome, can present with oedema of the hands. Involvement is often asymmetrical, resulting from severe tenosynovitis of the flexor tendons, with the typical sausage fingers. Lymphoedema, resulting from impaired lymphatic function (confirmed by isotope lymphography), has also been reported in psoriatic spondylarthropathy.26-28Unlike the oedema of RS3PE, the oedema is firm, non-pitting and usually affects the entire forearm or arm. Interestingly, these cases seem to benefit more from NSAIDs than corticosteroids.

    Late onset peripheral spondylarthropathy

    Pitting oedema is a feature of late onset peripheral spondylarthropathy as described by Dubost et al,29 but unlike RS3PE, it affects mainly the lower limb (involvement of the hands is rare) and is often asymmetrical.29 ,30 Patients are middle aged men (slightly younger than in RS3PE with an average around 60) appearing severely ill with prominent constitutional symptoms. Axial involvement is usually absent but mild oligoarthritis of the lower limbs is typical. Unlike RS3PE, response to NSAIDs and corticosteroids is poor and the disease remains active generally for several years. Finally, in all the cases described, HLA-B27 was positive.31

    Rheumatoid arthritis

    Rheumatoid arthritis in the elderly population (reviewed by van Schaardenburg and Breedveld32) presents more frequently with abrupt and polymyalgia-like onset with limb girdle symptoms. Eleven to 48% are also rheumatoid factor negative.32 However, pitting oedema is not a specific feature of rheumatoid arthritis. Rarely, oedema of the hands have been observed during severe flare ups and hence attributed to changed capillary permeability secondary to the diffuse inflammatory process.33 Unilateral oedema resulting from a capsular rupture at the wrist, similar to the Baker cyst rupture in the knees, has also been reported.33 Finally, a few rare cases of a firm, non-pitting lymphoedema, affecting the entire arm and attributed to lymphangitis secondary to the rheumatoid process, have been described.27 ,34-38 Lymphoscintigraphy35 as well as lymphography34 demonstrated changes in lymphatic drainage. Unlike the prompt response observed in RS3PE, these cases of rheumatoid lymphoedema do not respond well to second line treatment or corticosteroids.27 ,34 ,35 Demonstration of erosions or positive rheumatoid factor exclude the diagnosis of RS3PE, while high leucocyte counts in synovial fluid favours the diagnosis of rheumatoid arthritis. Nevertheless, immediate differentiation with RS3PE could be impossible and only dramatic response to low dose corticosteroids and long term remission after withdrawal will allow definite diagnosis.

    Polymyalgia rheumatica

    Probably the toughest differential diagnosis of RS3PE, polymyalgia rheumatica has to be considered in an elderly patient who develops an acute inflammatory syndrome, morning stiffness, shoulder girdle pain, and hand oedema. Although pitting oedema of the hands is not a classic feature of polymyalgia rheumatica, the Mayo Clinic reported pitting oedema in 19 of 245 cases of polymyalgia rheumatica.39 Three additional cases were later reported by Caliani et al.40 McCarty maintained that he had personally never seen, in almost 40 years of practice, the dramatic oedema as found in RS3PE in polymyalgia.41

    Polymyalgia is more frequent in women, with a sex ratio between 1.5 to 2:1, depending on the cohort studied.42 ,43 It involves the shoulder girdle in about 100% of the cases, but also very frequently the pelvic girdle (between 65 to 79%),42-44compared with RS3PE where it is much rarer. Also, true peripheral synovitis, usually mild, is found in only 5 to 15% of the cases.45-47 Although polymyalgia rheumatica responds dramatically to prednisone as RS3PE, flares are frequent and the duration of treatment much longer.48 Finally, HLA typing demonstrated increased prevalence of B7 for RS3PE but DR4 for polymyalgia,49-52 pointing toward similar but distinctive syndromes in this elderly population.